Comparison of epicardial cryoablation and irrigated radiofrequency ablation in a Swine infarct model

Journal of Cardiovascular Electrophysiology
Miguel E Jauregui-AbularachEdward P Gerstenfeld

Abstract

Epicardial Cryoablation in Swine. Cryoablation is an alternative to radiofrequency (RF) energy used in some ablation procedures. Its role and effectiveness compared to irrigated RF in epicardial tissue and epicardial substrates is not yet fully established. Using a swine chronic infarct model, we compared RF lesions produced by an open-irrigated 3.5 mm tip catheter with those produced by an 8 mm tip cryocatheter in epicardial infarct border zone, epicardial normal tissue, and normal endocardium. In the infarct border zone, cryolesions were larger than RF lesions in maximum diameter (9.3 ± 2.9 mm vs 6.2 ± 2 mm, P < 0.001) and volume (171.7 ± 173.1 mm(3) vs 77 ± 53.5 mm(3) , P = 0.021). In normal epicardial tissue, cryolesions were larger in maximum diameter (11.2 ± 4.3 mm vs 7.7 ± 3.1 mm, P = 0.012), depth (5.8 ± 1.6 mm vs 4.7 ± 1.4 mm, P = 0.034), and volume (274.7 ± 242.2 mm(3) vs 112 ± 102.9 mm(3) , P = 0.002). In normal endocardium, no significant differences were found. Epicardial cryoablation with an 8 mm tip cryocatheter led to larger lesion volume in infarcted myocardium compared to a 3.5 mm irrigated RF catheter. This is likely related to a combination of cryoadherence, more efficient energy delivery with horizontal ori...Continue Reading

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Citations

Nov 8, 2015·Circulation. Arrhythmia and Electrophysiology·Babak NazerEdward P Gerstenfeld
Mar 16, 2017·Circulation. Arrhythmia and Electrophysiology·Babak NazerEdward P Gerstenfeld
Jan 15, 2019·Journal of the American Heart Association·Susumu MorosawaHiroaki Shimokawa
Apr 13, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jackson J LiangSanjay Dixit
Jul 27, 2017·Pacing and Clinical Electrophysiology : PACE·Shailendra UpadhyayJ Philip Saul
Jan 2, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Babak NazerJonathan R Lindner

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