Comparison of Epithelium-Off Versus Transepithelial Corneal Collagen Cross-Linking for Keratoconus: A Systematic Review and Meta-Analysis

Cornea
Daizong WenJinhai Huang

Abstract

To systematically compare standard epithelium-off corneal collagen cross-linking (SCXL) and transepithelial corneal collagen cross-linking (TECXL) for treating keratoconus. PubMed, EMBASE, the Cochrane Library, the US trial registry (ClinicalTrials.gov), VIP Database, Wanfang Databse, and China National Knowledge Infrastructure searches up to February 2017 were conducted. Primary outcomes were changes at 1 year in uncorrected distance visual acuity, maximum keratometry (Kmax), and mean keratometry (mean K). Secondary outcomes were changes at 1 year in corrected distance visual acuity, mean refractive spherical equivalent, central corneal thickness, endothelial cell density, and the occurrence of adverse events. Eight studies with a total of 455 eyes were included. For primary outcomes, SCXL showed a greater reduction in mean K [standardized mean difference (SMD) 0.28; 95% confidence interval (CI), 0.03-0.53; P = 0.03] compared with TECXL. Subgroup analysis indicated that SCXL had a comparable effect on reducing mean K with TECXL protocols using chemical enhancers (SMD 0.05; 95% CI, -0.36 to 0.45; P = 0.82) but a greater reduction in mean K compared with TECXL with current iontophoretic protocols (SMD 0.43; 95% CI, 0.10-0.75; P ...Continue Reading

References

Jan 1, 1984·Survey of Ophthalmology·J H KrachmerM W Belin
Mar 11, 1998·Survey of Ophthalmology·Y S Rabinowitz
Jun 17, 1998·Experimental Eye Research·E SpoerlT Seiler
Apr 30, 2003·American Journal of Ophthalmology·Gregor WollensakTheo Seiler
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jun 13, 2008·Acta Ophthalmologica·Gregor Wollensak, Elena Iomdina
Sep 25, 2008·Journal of Refractive Surgery·Christine Wittig-SilvaGrant R Snibson
Aug 12, 2009·The British Journal of Ophthalmology·P T Ashwin, P J McDonnell
Jun 12, 2010·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Miguel Romero-JiménezJames S Wolffsohn
Dec 25, 2010·Journal of Cataract and Refractive Surgery·Peter S HershKristen L Fry
Jan 1, 2009·Oman Journal of Ophthalmology·Maria Clara ArbelaezSanak Roy Choudhury
Feb 22, 2012·Journal of Cataract and Refractive Surgery·Nneka O BrooksPeter S Hersh
Jan 26, 2013·Journal of Refractive Surgery·Luca Buzzonetti, Gianni Petrocelli
Feb 20, 2013·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Marie Eve LegareDavid S Rootman
Apr 16, 2013·The Ocular Surface·Frederik Raiskup, Eberhard Spoerl
Jun 25, 2013·Journal of Cataract and Refractive Surgery·Abdelrahman G Salman
Aug 31, 2014·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Maddalena De BernardoNicola Rosa
Dec 4, 2014·Journal of Cataract and Refractive Surgery·Sebastian P Lesniak, Peter S Hersh
Aug 20, 2015·Journal of Cataract and Refractive Surgery·Eren ÇermanDeniz Ozarslan Ozcan
Aug 27, 2015·American Journal of Ophthalmology·David P S O'BrartNaomi A O'Brart
Dec 17, 2015·Investigative Ophthalmology & Visual Science·Daniel M GoreBruce D Allan
Dec 24, 2016·European Journal of Ophthalmology·David P S O'Brart
Jan 1, 2017·American Journal of Ophthalmology·Daniel A GodefrooijRobert P L Wisse

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Citations

Feb 13, 2020·Journal of Cataract and Refractive Surgery·Colm McAlindenKonrad Pesudovs
Jul 30, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Huping WuZuguo Liu
Sep 5, 2020·Clinical Ophthalmology·Ana Maria CunhaJoão Pinheiro-Costa
Dec 7, 2020·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Ali Mahdavi FardNader D Nader
Mar 26, 2021·The Cochrane Database of Systematic Reviews·Sueko M NgIrene C Kuo
Sep 5, 2020·Journal of Optometry·Ángeles Arance-GilRamón Gutiérrez-Ortega
Aug 6, 2021·Frontiers in Pharmacology·Duoduo WuChris Hong Long Lim
Aug 14, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Devanshi JaniStuti L Misra
Aug 28, 2021·International Ophthalmology·Sebastiano SerraoMarco Lombardo
Feb 4, 2022·PloS One·Denise WajnsztajnAbraham Solomon

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