Comparison of estimated glomerular filtration rate equations at the time of hemodialysis initiation

Kidney Research and Clinical Practice
Min-Jeong LeeGyu-Tae Shin

Abstract

Estimated glomerular filtration rate (eGFR) is one of the most important guidelines in deciding the optimal timing of dialysis initiation. In the present study, we calculated the eGFR at the time of hemodialysis (HD) initiation using 5 commonly used equations to relate them with clinical and laboratory characteristics of the patients and to evaluate which of these equations best define the eGFR at HD initiation. We retrospectively analyzed 409 end-stage renal disease patients who were newly started on HD treatment in our institution. The eGFR was calculated using the Cockcroft-Gault equation, the Cockcroft-Gault equation corrected for body surface area, the Modification of Diet in Renal Disease (MDRD) equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, and the Nankivell equation. The mean eGFRs at HD start were significantly different across the equations. The mean eGFR was 7.8 mL/min for the corrected Cockcroft-Gault equation, 7.7 mL/min for the Cockcroft-Gault equation, 6.2 mL/min/1.73 m(2) for the MDRD equation, and 5.6 mL/min/1.73 m(2) for the CKD-EPI equation. The corrected Cockcroft-Gault, the MDRD, and the CKD-EPI equations were well correlated with all CKD-specific complications including...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jun 27, 1995·Transplantation·B J NankivellJ R Chapman
Jul 4, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN Hemodialysis Adequacy 2006 Work Group
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jun 29, 2010·The New England Journal of Medicine·Bruce A CooperUNKNOWN IDEAL Study
Jul 17, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Seth WrightAlexander S Goldfarb-Rumyantzev
Apr 27, 2012·Kidney International·Christopher W McIntyre, Steven J Rosansky
Oct 24, 2012·Journal of Korean Medical Science·Jae Hyun ChangSejoong Kim
Feb 11, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Deidra C CrewsUNKNOWN DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators
Mar 13, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Joanne M Bargman

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Citations

Mar 23, 2019·Kidney Research and Clinical Practice·Changhyun LeeSeung Hyeok Han
Jan 31, 2020·Kidney & Blood Pressure Research·Ying LiuUNKNOWN on behalf of the DIFE Study Group

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Software Mentioned

SPSS
IDEAL
Statistical Package for Social Sciences ( SPSS

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