Comparison of ethanol concentrations in the human brain determined by magnetic resonance spectroscopy and serum ethanol concentrations.

International Journal of Legal Medicine
Annette Thierauf-EmbergerThomas Lange

Abstract

Ethanol is a widespread substance that inherits desired effects, but also negative consequences with regard to DUI or battery. Where required, the ethanol concentration is usually determined in peripheral venous blood samples, while the brain is the target organ of the ethanol effects. The aim of this study with three participants was the determination of the ethanol concentration in functionally relevant regions of the brain and the comparison with serum ethanol concentrations. After the uptake of ethanol in a calculated amount, leading to a serum ethanol concentration of 0.99 g/L, the ethanol concentrations in the brain were directly analyzed by means of magnetic resonance spectroscopy on a 3 Tesla human MRI system and normalized to the water content. The measurement voxels were located in the occipital cortex, the cerebellum, the frontal cortex, and the putamen and successively examined. Intermittently blood samples were taken, and serum was analyzed for ethanol using HS-GC-FID. Ethanol concentrations in brain regions normalized to the water content were lower than the measured serum ethanol results and rather homogenous within the three participants and the various regions of the brain. The maximum ethanol concentration in ...Continue Reading

References

Sep 1, 1990·Alcohol·J H MendelsonM Dobrosielski
Apr 1, 1983·Journal of Chromatography·R D Budd
Jan 1, 1982·Forensic Science International : Synergy·J BonventreM L Bastos
Oct 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T M ChiuN K Mello
Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Dec 29, 1995·Forensic Science International : Synergy·T TakayasuT Nagano
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M J KaufmanN K Mello
Apr 18, 1997·Forensic Science International : Synergy·K A MooreT M Hyde
Nov 26, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonN D Volkow
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M K SammiH P Hetherington
Jun 19, 2001·NMR in Biomedicine·S CavassilaD Graveron-Demilly
Oct 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tom W J ScheenenArend Heerschap
Feb 26, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Armin BillerMartin Bendszus
Dec 19, 2009·Methods : a Companion to Methods in Enzymology·Graham S FloryChristopher D Kroenke
Mar 7, 2019·Frontiers in Molecular Neuroscience·Benjamin SpurnyRupert Lanzenberger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.