PMID: 1684888Dec 1, 1991Paper

Comparison of European isolates of viruses causing hemorrhagic fever with renal syndrome by a neutralization test

The American Journal of Tropical Medicine and Hygiene
B NiklassonE A Tkachenko


Different virus isolates causing hemorrhagic fever with renal syndrome (HFRS) were compared using a neutralization test. Patient convalescent sera and antisera prepared in rabbits were used to compare Puumala-related Hantavirus isolates from Finland, Sweden, Belgium, and the USSR. The majority of European isolates were indistinguishable from each other using both homologous rabbit antisera and patient convalescent sera. The European isolates of HFRS were also compared with prototype Hantaan (the etiologic agent of Korean hemorrhagic fever). The one-way cross-reaction between the Hantaan and Puumala viruses, previously described using human convalescent sera tested by indirect immunofluorescence and immunoprecipitation, was also seen by the neutralization test.


Jul 2, 2015·Memórias do Instituto Oswaldo Cruz·Michelly de PáduaLuiz Tadeu Moraes Figueiredo
Oct 28, 2017·PLoS Neglected Tropical Diseases·Valentijn VergotePiet Maes
Oct 12, 2002·Journal of Medical Virology·Irina GolovljovaA Lundkvist
May 1, 1997·Journal of Virology·T HeiskanenH Lankinen
Dec 17, 1997·Journal of Clinical Microbiology·K B SjölanderA Lundkvist
Feb 1, 1995·Journal of Clinical Microbiology·J HörlingB Niklasson

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