Abstract
This blinded, single center study prospectively compares exercise electron beam computed tomography (EBCT) with stress technetium-99m (Tc-99m) sestamibi single-photon emission computed tomography (SPECT) in 33 patients undergoing coronary angiography for evaluation of chest pain. Patients undergoing routine cardiac catheterization for the diagnosis of chest pain were imaged at rest using EBCT. Patients exercised on a semi-supine ergometer, and exercise EBCT was immediately followed by injection of Tc-99m sestamibi for assessment of myocardial ischemia. At peak exercise, Tc-99m SPECT, followed immediately by nonionic contrast material, was injected intravenously to directly compare these 2 imaging techniques. Patients were reimaged with Tc-99m SPECT at rest 24 to 48 hours after stress. Exercise EBCT, which was analyzed using a global ejection fraction measure, had a sensitivity of 81% and a specificity of 76%, compared with angiography. Using the development of a new regional wall motion abnormality as evidence of obstructive coronary artery disease (CAD), EBCT yielded a specificity of 100% and a sensitivity of 88%. Reversible perfusion defects identified by SPECT, as evidence of obstructive CAD, revealed a sensitivity of 75% an...Continue Reading
References
Sep 1, 1979·Circulation·J S BorerG S Johnston
Aug 1, 1989·American Heart Journal·E A RodriguesD S Berman
Apr 1, 1989·Journal of the American College of Cardiology·E RoigB H Brundage
Aug 1, 1988·Journal of the American College of Cardiology·A J FeiringM L Marcus
Aug 1, 1986·Circulation·F H SheehanH W Woo
Jan 1, 1985·International Journal of Cardiac Imaging·J S GarrettM J Lipton
Jan 1, 1985·Journal of the American College of Cardiology·M J LiptonD P Boyd
Sep 1, 1981·Circulation·R H JonesD C Sabiston
Apr 1, 1983·Journal of the American College of Cardiology·N L DePaceB L Segal
Jan 1, 1983·The American Journal of Cardiology·D E Manyari, W J Kostuk
Apr 1, 1981·The American Journal of Cardiology·W L SchoolmeesterR D Fletcher
Nov 1, 1981·Circulation·R J GibbonsR H Jones
Jan 1, 1980·Circulation·R D OkadaG M Pohost
Mar 1, 1996·Circulation·M J BudoffB H Brundage
Sep 1, 1996·Circulation·L WexlerK Taubert
Dec 1, 1992·Current Opinion in Cardiology·R Coulden, M J Lipton
Citations
Jul 18, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Udo HoffmannJohn T Nagurney
Jun 23, 1999·Chest·B P MandalapuH G Stratmann
Mar 12, 2008·Circulation·Ilan Gottlieb, João A C Lima
Sep 24, 2010·Journal of Computer Assisted Tomography·Yasmin S HamiraniMatthew J Budoff
Apr 3, 2001·Investigative Radiology·T C GerberT Behrenbeck