Abstract
Tularemia is a zoonotic disease caused by Francisella tularensis, which is transmitted to humans most commonly by contact with infected animals, tick bites, or inhalation of aerosolized bacteria. F. tularensis is highly infectious via the aerosol route; inhalation of as few as 10-50 organisms can cause pneumonic tularemia. Left untreated, the pneumonic form has more than >30% case-fatality rate but with early antibiotic intervention can be reduced to 3%. This study compared tularemia disease progression across three species of nonhuman primates [African green monkey (AGM), cynomolgus macaque (CM), and rhesus macaque (RM)] following aerosolized F. tularensis Schu S4 exposure. Groups of the animals exposed to various challenge doses were observed for clinical signs of infection and blood samples were analyzed to characterize the disease pathogenesis. Whereas the AGMs and CMs succumbed to disease following challenge doses of 40 and 32 colony forming units (CFU), respectively, the RM lethal dose was 276,667 CFU. Following all challenge doses that caused disease, the NHPs experienced weight loss, bacteremia, fever as early as 4 days post exposure, and tissue burden. Necrotizing-to-pyogranulomatous lesions were observed most commonly...Continue Reading
References
Aug 6, 1997·JAMA : the Journal of the American Medical Association·G W ChristopherE M Eitzen
Jun 21, 2001·JAMA : the Journal of the American Medical Association·D T DennisUNKNOWN Working Group on Civilian Biodefense
Dec 13, 2003·Journal of Pharmacological and Toxicological Methods·Justin M Hartings, Chad J Roy
Nov 20, 2004·Nature Reviews. Microbiology·Petra C F OystonRichard W Titball
Jan 5, 2006·Clinical Chemistry·Deanna R ChristensenDavid A Norwood
Mar 31, 2007·Annals of the New York Academy of Sciences·C Rick Lyons, Terry H Wu
Mar 12, 2009·Veterinary Pathology·N A TwenhafelB K Purcell
May 1, 2013·Veterinary Pathology·M V StundickJ C Larsen
Feb 1, 2014·Comparative Immunology, Microbiology and Infectious Diseases·C L CarvalhoE L Duarte
Citations
Mar 25, 2016·Expert Review of Vaccines·Karen L ElkinsRoberto De Pascalis
Jun 1, 2017·Antimicrobial Agents and Chemotherapy·Trudy H GrossmanJoyce A Sutcliffe
Oct 23, 2018·PloS One·Katherine J O'MalleyDouglas S Reed
Aug 31, 2018·Radiation Research·Andrea L DiCarloPaul W Price
Mar 16, 2017·Frontiers in Microbiology·Ronit Aloni-GrinsteinRaphael Ber
Apr 24, 2018·Frontiers in Cellular and Infection Microbiology·Lydia M RobertsJeffrey A Frelinger
Jun 6, 2018·Frontiers in Cellular and Infection Microbiology·Qingmei Jia, Marcus A Horwitz
Nov 7, 2019·Frontiers in Medicine·Mark S WilliamsPhillip R Pittman
Jun 27, 2019·Scientific Reports·Deyu TianShigeru Morikawa
Apr 20, 2018·Frontiers in Cellular and Infection Microbiology·Tina GuinaJudith A Hewitt
Apr 23, 2020·Neuron·Anna Yu-Szu HuangBenjamin Deneen
Jun 3, 2021·Pathogens·Ondraya M FrickAysegul Nalca
Jun 3, 2021·Pathogens·Julie A LovchikTerry H Wu
Aug 31, 2021·Frontiers in Microbiology·Beth A BachertJoel A Bozue