Comparison of Eye Movement Desensitization Reprocessing and Cognitive Behavioral Therapy as Adjunctive Treatments for Recurrent Depression: The European Depression EMDR Network (EDEN) Randomized Controlled Trial

Frontiers in Psychology
Luca OstacoliArne Hofmann

Abstract

Background: Treatment of recurrent depressive disorders is currently only moderately successful. Increasing evidence suggests a significant relationship between adverse childhood experiences and recurrent depressive disorders, suggesting that trauma-based interventions could be useful for these patients.Objectives:To investigate the efficacy of Eye Movement Desensitization and Reprocessing therapy (EMDR) in addition to antidepressant medication (ADM) in treating recurrent depression.Design:A non-inferiority, single-blind, randomized clinical controlled trial comparing EMDR or CBT as adjunctive treatments to ADM. Randomization was carried out by a central computer system. Allocation was carried out by a study coordinator in each center.Setting:Two psychiatric services, one in Italy and one in Spain.Participants:Eighty-two patients were randomized with a 1:1 ratio to the EMDR group (n= 40) or CBT group (n= 42). Sixty-six patients, 31 in the EMDR group and 35 in the CBT group, were included in the completers analysis.Intervention:15 ± 3 individual sessions of EMDR or CBT, both in addition to ADM. Participants were followed up at 6-months.Main outcome measure: Rate of depressive symptoms remission in both groups, as measured by a B...Continue Reading

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Citations

Nov 26, 2019·European Journal of Psychotraumatology·Corine PaauwAlexandra Dingemans
Dec 15, 2020·Substance Abuse : Research and Treatment·Stephen DansigerJustine Kovacs
Dec 29, 2020·Psychoneuroendocrinology·Rosana Carvalho SilvaAlessandra Minelli
Apr 24, 2021·European Journal of Psychotraumatology·Sara CarlettoLuca Ostacoli
Jul 23, 2021·PloS One·Sarah K DominguezChristopher William Lee
Oct 8, 2021·Frontiers in Psychology·Charles Scelles, Luis Carlo Bulnes

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Methods Mentioned

BETA
Cognitive Behavioral Therapy

Clinical Trials Mentioned

ISRCTN09958202

Software Mentioned

DeprEnd
ADDPLAN
Statistical Package for Social Sciences ( SPSS

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