Comparison of F-18 FDG-PET/CT and Tc-99m MIBI in the preoperative evaluation of cold thyroid nodules in the same patient group

Endocrine
Sait SagerBedii Kanmaz

Abstract

Recent studies have reported that standardized uptake values of FDG-PET imaging might predict malignant thyroid nodules and can be used in the preoperative evaluation of thyroid lesions. The aim of our study was to evaluate FDG-PET imaging in patients with cold thyroid nodules and to compare the imaging findings with Tc-99m MIBI scans and with post-op histopathology results. Twenty-three patients (18F, 5M) with 24 nodules that were suspicious in ultrasound and cold in Tc-99m pertechnetate scan, were included in the study. Each nodule underwent sonographically guided fine-needle aspiration biopsy. FDG-PET and MIBI scans were performed with an interval of 3-5 days. All patients underwent thyroidectomy and their FDG-PET, and MIBI thyroid scan results were compared with post-thyroidectomy pathology results. Post-op histopathology results found 7 malignant and 17 benign nodules. Six of the seven malignant nodules had increased uptake, which were positive for malignancy in both PET and MIBI scans. Each imaging method used different radiopharmaceuticals but showed one false-negative result in two different patients. FDG-PET produced false positives in eight nodules and MIBI scans found false positives in four nodules. FDG-PET imaging ...Continue Reading

References

Mar 10, 2001·Nuclear Medicine Communications·A SarikayaS Berkarda
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Annick Van den BruelRoger Bouillon
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Erik K AlexanderEllen Marqusee
Nov 18, 2004·American Journal of Surgery·Barbara MillerFiemu E Nwariaku
Jun 22, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Luis-Mauricio Hurtado-López, Carlos Martínez-Duncker
Feb 29, 2008·The Oncologist·Meei J Yeung, Jonathan W Serpell
Feb 17, 2010·Archives of Otolaryngology--head & Neck Surgery·Ali RazfarRobert L Ferris
Jan 22, 2011·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Hidefumi NishimoriJacques How
Apr 21, 2011·Endocrine·Tsung-Ying HoTzu-Chen Yen
May 26, 2012·Indian Journal of Endocrinology and Metabolism·Vikas Chaudhary, Shahina Bano
Jun 7, 2012·Thyroid : Official Journal of the American Thyroid Association·Carrie C LubitzSareh Parangi
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward
Oct 12, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Frederik A VerburgAlexander Heinzel

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