Comparison of Fasting Human Pancreatic Polypeptide Levels Among Patients With Pancreatic Ductal Adenocarcinoma, Chronic Pancreatitis, and Type 2 Diabetes Mellitus

Pancreas
Sajan Jiv Singh NagpalSuresh T Chari

Abstract

Human pancreatic polypeptide (HPP) is a hormone secreted by the ventral pancreas. While postprandial HPP levels have been studied in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), there are limited data on fasting HPP in these diseases. Fasting serum HPP was measured in the following groups of patients: CP with diabetes mellitus (DM) (n = 16), CP without DM (n = 34), PDAC with new-onset DM (n = 50), PDAC without DM (n = 49), new-onset type 2 DM (n = 50), and controls without DM (n = 49). Sixty-six had type 3c DM (CP with DM, n = 16; PDAC with new-onset DM, n = 50). Median fasting HPP levels (in picograms per milliliter) were similar among all groups. Median (interquartile range) HPP levels in new-onset type 2 DM (n = 50; 288.3 [80.1-1072.1]) were similar to those in type 3c DM (n = 66; 242.3 [64.9-890.9]) (P = 0.71). In PDAC (n = 99), HPP values were similar in pancreatic head (n = 75) versus body/tail (n = 24) tumors (245.3 [64.3-1091.3] vs 334.7 [136.1-841.5]; P = 0.95), regardless of DM. Fasting HPP levels are similar in CP, PDAC, and controls regardless of glycemic status.

References

Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Apr 28, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Suresh T ChariRobert A Rizza
Oct 23, 2008·Oral Diseases·S HameedS R Bloom
Feb 5, 2013·European Journal of Internal Medicine·Nils Ewald, Reinhard G Bretzel
Mar 27, 2013·Nature Reviews. Gastroenterology & Hepatology·Raghuwansh P SahSuresh T Chari
Jul 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Michael R RickelsUNKNOWN PancreasFest Recommendation Conference Participants
Oct 31, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naureen JaveedDebabrata Mukhopadhyay
Mar 15, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Phil A HartSuresh T Chari
Dec 24, 2015·Diabetes Care·UNKNOWN American Diabetes Association
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·Phil A HartUNKNOWN Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer(CPDPC)

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Citations

Aug 28, 2020·World Journal of Diabetes·Ayan RoyBiju Pottakkat
Jan 8, 2021·International Journal of Cancer. Journal International Du Cancer·Jingru YuWeimin Ye
Jul 16, 2021·Current Opinion in Gastroenterology·Phil A HartMark O Goodarzi

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