Comparison of Features of Fatal Versus Nonfatal Cardiac Arrest in Patients With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

The American Journal of Cardiology
Richa GuptaCynthia James

Abstract

Once arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is diagnosed, the incidence of sudden cardiac death (SCD) is rare and prognosis is favorable, highlighting the value of early disease recognition. To inform strategies to diagnose ARVD/C before SCD, we sought to characterize clinical, genetic, and family history features of ARVD/C cases first recognized after SCD or resuscitated SCD (sudden cardiac arrest [SCA]). We identified 66 ARVD/C cases submitted to the Johns Hopkins ARVD/C Registry in whom disease was first recognized after SCD (n = 45) or SCA (n = 21) and compared their clinical, genetic, and demographic features with 352 patients (227 probands) diagnosed with ARVD/C by 2010 Task Force Criteria before any arrest. SCD/SCA cases were 65% men and experienced their arrest at 29.3 ± 13.8 years. Exertion precipitated 72% of arrests. Family history was recognized before arrest in 11 cases (17%), and 24 cases (41%) had reported cardiac symptoms before arrest. The SCD/SCA cohort was disproportionately men (65% SCD/SCA vs 50% living, p = 0.03) and younger at both first reported symptom (27.7 ± 13.5 years SCD/SCA vs 33.0 ± 13.6 years living, p = 0.01) and first sustained ventricular arrhythmia (VA) (29.3 ± 13....Continue Reading

Citations

Jun 13, 2018·Journal of Cardiovascular Electrophysiology·Weijia WangHugh Calkins
Aug 7, 2018·Journal of Cardiovascular Electrophysiology·Amalio Ruiz SalasJavier Alzueta
Jun 20, 2018·Circulation·Daniel P Judge, Emily E Brown
Nov 22, 2017·Circulation·Hugh CalkinsFrank Marcus
Nov 27, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jerome MontnachMario Delmar
Oct 26, 2018·Annual Review of Medicine·Cynthia A James, Hugh Calkins
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Apr 16, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Laurens P BosmanAnneline S J M Te Riele
Aug 30, 2020·European Heart Journal·Antonio PellicciaUNKNOWN ESC Scientific Document Group
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May 4, 2021·Arrhythmia & Electrophysiology Review·Ryan Wallace, Hugh Calkins
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Nov 5, 2021·Frontiers in Cardiovascular Medicine·Julia Martínez-SoléEsther Zorio

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