Comparison of Fecal Inflammatory Markers in Crohn's Disease

Inflammatory Bowel Diseases
Emily K WrightRichard B Gearry

Abstract

Fecal biomarkers are used increasingly to monitor Crohn's disease (CD). However, the relative accuracy of different markers in identifying inflammation has been poorly evaluated. We evaluated fecal calprotectin (FC), lactoferrin (FL), and S100A12 (FS) using endoscopic validation in a prospective study of the progression of CD after intestinal resection. Data were collected from 135 participants in a prospective, randomized, controlled trial aimed at preventing postoperative CD recurrence. Three hundred nineteen stool samples were tested for FC, FL, and FS preoperatively and 6, 12, and 18 months after resection. Colonoscopy was performed at 6 and/or 18 months. Endoscopic recurrence was assessed blindly using the Rutgeerts score. C-reactive protein (CRP) and Crohn's Disease Activity Index (CDAI) were assessed. FC, FL, and FS concentrations were elevated preoperatively (median: 1347, 40.9, and 8.4 μg/g, respectively). At 6 months postoperatively, marker concentrations decreased (166, 3.0, 0.9 μg/g) and were higher in recurrent disease than remission (275 versus 72 μg/g, P < 0.001; 5.7 versus 1.6 μg/g, P = 0.007; 2.0 versus 0.8 μg/g, P = 0.188). FC > 135 μg/g, FL > 3.4 μg/g, and FS > 10.5 μg/g indicated endoscopic recurrence (score...Continue Reading

References

Sep 1, 1992·Scandinavian Journal of Gastroenterology·A G RøsethH Schjønsby
Aug 28, 1999·The Journal of Biological Chemistry·T VoglJ Roth
Oct 29, 2000·The American Journal of Gastroenterology·P J LimburgA R Zinsmeister
Jun 5, 2003·Drugs of Today·J. A. Tibble, I. Bjarnason
Jun 24, 2003·The American Journal of Gastroenterology·Sunanda V KaneStephen B Hanauer
Oct 18, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F CostaG Maltinti
May 1, 2004·Annals of Clinical Biochemistry·Julie WassellAnthony Hawthorne
Aug 18, 2004·Digestive Diseases and Sciences·Stephan BuderusMichael J Lentze
Mar 30, 2005·Journal of Pediatric Gastroenterology and Nutrition·Ulrika Lorentzon FagerbergYigael Finkel
Jun 29, 2006·Inflammatory Bowel Diseases·Naomi S H de JongAndrew S Day
Jul 14, 2006·International Journal of Colorectal Disease·Renata D'IncàGiacomo Carlo Sturniolo
Feb 28, 2007·The American Journal of Gastroenterology·Alexander C von RoonParis P Tekkis
Apr 7, 2007·Journal of Pediatric Gastroenterology and Nutrition·Thomas R WalkerPaul A Rufo
May 3, 2007·Diseases of the Colon and Rectum·Marco ScarpaImerio Angriman
Jun 20, 2007·Inflammatory Bowel Diseases·Guy Chung-FayeRoy Sherwood
Sep 1, 2007·Diseases of the Colon and Rectum·Alain M SchoepferFrank Seibold
Sep 14, 2007·Scandinavian Journal of Gastroenterology·Jun DaiZhi-Zheng Ge
Feb 2, 2008·Inflammatory Bowel Diseases·Dorota WalkiewiczSubra Kugathasan
Jul 8, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J P Gisbert, A G McNicholl
Sep 19, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jennifer JonesWilliam J Sandborn
Sep 20, 2008·The American Journal of Gastroenterology·Renata D'IncàGiacomo Carlo Sturniolo
Dec 27, 2008·Gastroenterology·Miguel RegueiroScott E Plevy
Jan 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Manohara JoishyHuw Jenkins
Mar 18, 2009·Inflammatory Bowel Diseases·Javier P GisbertJosé Maté
Apr 23, 2009·The British Journal of Surgery·C A LambJ C Mansfield
Jul 8, 2009·European Journal of Gastroenterology & Hepatology·Lamia KallelAzza Filali
Oct 17, 2009·Inflammatory Bowel Diseases·Bjørn MoumTomm Bernklev
Dec 26, 2009·Scandinavian Journal of Gastroenterology·Taina SipponenKaija-Leena Kolho

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Citations

Jul 15, 2017·Expert Review of Gastroenterology & Hepatology·Takayuki Yamamoto, Takahiro Shimoyama
Feb 15, 2018·Acta Medica (Hradec Králové)·Paula MorávkováJan Bureš
Oct 20, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Teminioluwa A AjayiMichael B Fessler
Aug 24, 2018·Journal of Crohn's & Colitis·Christian MaaserUNKNOWN European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR
Oct 15, 2019·Journal of Parkinson's Disease·Tomasz Brudek

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