Comparison of Fenestra VC Contrast-enhanced computed tomography imaging with gadopentetate dimeglumine and ferucarbotran magnetic resonance imaging for the in vivo evaluation of murine liver damage after ischemia and reperfusion

Investigative Radiology
Alexander ChoukèrManfred Thiel

Abstract

Comparison of intravenous Fenestra VC-enhanced computed tomography (CT) with gadopentetate dimeglumine and Ferucarbotran contrast-enhanced magnetic resonance imaging (MRI) for the in vivo imaging of hepatic ischemia/reperfusion injury (IRI) in a murine model. After induction of hepatic IRI by left liver lobe (LLL) ischemia (30, 45, and 75 minutes) and reperfusion (4 hours and 24 hours), a total of 130 mice were imaged either by Fenestra VC-enhanced 3-D CT or by dynamic, T1-weighed gadopentetate dimeglumine or static, T2*-weighed Ferucarbotran 2-D MRI (4.7 T). Detection of liver tissue damage as a consequence of IRI was not possible by CT or MRI without the use of contrast media. (1) Mice subjected to liver IRI (45 minutes of ischemia) and injected with Fenestra VC showed a distinct liver enhancement of the viable liver tissue or a nonenhancement of the necrotic tissue. The Fenestra VC CT-unenhanced liver volume increased as a function of time of ischemia and reperfusion. The unenhanced liver volume also correlated positively with serum liver enzyme activities and damage scores from liver histology. (2) The signal intensities (SI) between normal liver tissue and livers subjected to 30 minutes of ischemia were not different on dy...Continue Reading

References

Feb 17, 1995·Journal of Medicinal Chemistry·J P WeichertR E Counsell
May 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·P ReimerP E Peters
Sep 18, 1999·Digestive Diseases and Sciences·J ShimizuM Monden
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C PeraltaJ Roselló-Catafau
Aug 10, 2000·Journal of Magnetic Resonance Imaging : JMRI·V M Runge
Jan 12, 2001·Radiology·R C Semelka, T K Helmberger
Jun 27, 2001·American Journal of Surgery·F Serracino-InglottR T Mathie
Oct 2, 2001·La Presse médicale·R Cursio
Dec 26, 2001·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·J D LeeW S Mun
Jul 16, 2003·Journal of Gastroenterology and Hepatology·Narci C Teoh, Geoffrey C Farrell
Sep 2, 2003·Gastroenterology·Nazia SelznerPierre-Alain Clavien
Oct 15, 2003·Free Radical Biology & Medicine·Andrej KhandogaFritz Krombach
Nov 20, 2003·Topics in Magnetic Resonance Imaging : TMRI·Miles A Kirchin, Val M Runge
May 12, 2004·Radiologic Clinics of North America·Michelle M McNamaraMichelle L Robbin
Jan 1, 2005·European Radiology·Marie-France BellinUNKNOWN Members of Contrast Media Safety Committee of European Society of Urogenital Radiology (ESUR)
May 21, 2005·Journal of Magnetic Resonance Imaging : JMRI·Christoph BremerPeter Reimer
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael A Zimmerman, R Mark Ghobrial
Feb 1, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Omar Almusa, Michael P Federle
Oct 1, 1908·Annals of Surgery·J H Pringle

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Citations

Nov 20, 2015·Frontiers in Pharmacology·Jeffrey R AshtonCristian T Badea
Sep 30, 2009·Journal of Magnetic Resonance Imaging : JMRI·Jerry S CheungEd X Wu
Jul 24, 2008·Contrast Media & Molecular Imaging
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Gurpreet Singh SandhuJeffrey L Duerk
Apr 13, 2010·Investigative Radiology·Val M Runge
Nov 13, 2008·Investigative Radiology·Val M Runge
Sep 17, 2014·Anesthesiology·Quirin ZanglAlexander Choukèr
Jul 18, 2015·World Journal of Gastroenterology : WJG·Xiang-Wei HuaQiang Xia
Jan 14, 2021·Biomedical Physics & Engineering Express·Samir El Ketara, Nancy Lee Ford

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