Comparison of ferumoxytol-based cerebral blood volume estimates using quantitative R1 and R2* relaxometry

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Leonardo A Rivera-RiveraKevin M Johnson

Abstract

Cerebral perfusion is commonly assessed clinically with dynamic susceptibility contrast MRI using a bolus injection of gadolinium-based contrast agents, resulting in semi-quantitative values of cerebral blood volume (CBV). Steady-state imaging with ferumoxytol allows estimation of CBV with the potential for higher precision and accuracy. Prior CBV studies have focused on the signal disrupting T2* effects, but ferumoxytol also has high signal-enhancing T1 relaxivity. The purpose of this study was to investigate and compare CBV estimation using T1 and T2*, with the goal of understanding the contrast mechanisms and quantitative differences. Changes in R1 (1/T1 ) and R2* (1/ T2*) were measured after the administration of ferumoxytol using high-resolution quantitative approaches. Images were acquired at 3.0T and R1 was estimated from an ultrashort echo time variable flip angle approach, while R2* was estimated from a multiple gradient echo sequence. Twenty healthy volunteers were imaged at two doses. CBV was derived and compared from relaxometry in gray and white matter using different approaches. R1 measurements showed a linear dependence of blood R1 with respect to dose in large vessels, in contrast to the nonlinear dose-dependenc...Continue Reading

References

Feb 1, 1990·Brain : a Journal of Neurology·K L LeendersS Herold
Dec 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A Yablonskiy, E M Haacke
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M DonahueB R Rosen
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·K M DonahueD Burstein
May 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C SchwarzbauerA Haase
Feb 19, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y GossuinP Gillis
May 9, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D O WalshM W Marcellin
Mar 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·I TroprèsM Décorps
Jul 31, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H B LarssonT Fritz-Hansen
Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Atle BjørnerudHåkan K Ahlström
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·V G KiselevJ Hennig
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Nov 2, 2005·Journal of Magnetic Resonance Imaging : JMRI·Leif Østergaard
Feb 2, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hai-Ling Margaret Cheng, Graham A Wright
May 26, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B F KjølbyV G Kiselev
Aug 19, 2006·Stroke; a Journal of Cerebral Circulation·Vladimir HachinskiGabrielle G Leblanc
Dec 28, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vasily L Yarnykh
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Damian J TylerGraeme M Bydder
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jason M ZhaoPeter C M van Zijl
Oct 28, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rajender AgarwalCraig A Umscheid
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Jeffrey C Weinreb, Ali K Abu-Alfa
Nov 25, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Heiko SchmiedeskampRoland Bammer
Dec 6, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Samuel A HurleyAlexey A Samsonov
Dec 14, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O C RichardsonD L Buckley
Mar 2, 2012·Neurology·V DeramecourtR N Kalaria
Sep 25, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thomas ChristenGreg Zaharchuk
Mar 15, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Csanad G VarallyayEdward A Neuwelt
Jun 19, 2013·Neurology·Brian T FarrellEdward A Neuwelt
Aug 21, 2013·Nature Medicine·Kyrre E EmblemA Gregory Sorensen
Jul 1, 2014·Journal of Magnetic Resonance Imaging : JMRI·Mustafa R BashirRendon C Nelson
Sep 25, 2014·Journal of Internal Medicine·A E Roher
Apr 29, 2015·NMR in Biomedicine·William D RooneyCharles S Springer
Oct 29, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Guido Buonincontri, Stephen J Sawiak
Dec 15, 2015·Investigative Radiology·Anne M MueheHeike E Daldrup-Link
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leonardo A Rivera-RiveraOliver Wieben
Feb 19, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shreyas S VasanawalaMustafa R Bashir
Aug 3, 2016·Journal of Magnetic Resonance Imaging : JMRI·Kim-Lien NguyenJ Paul Finn

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Feb 14, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Leonardo A Rivera-RiveraTilman Schubert

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