Comparison of field and vaccine strains of Australian fowlpox viruses

Archives of Virology
David B BoyleBarbara E H Coupar

Abstract

The mild fowlpox vaccine, FPV M, widely used in Australia is composed of two predominant genotypes based upon differences identifiable in restriction enzyme analyses of plaque purified derivatives of this vaccine. The differences, where identifiable, were in the end fragments of the genomes. Five field isolates of FPV from chickens in New South Wales showed restriction enzyme profiles closely related to the more virulent (standard) vaccine strain, FPV S. The FPV S strain differs from FPV M in both terminal genome fragments and in the presence of a PstI fragment of approximately 10kb (this fragment was also present in PstI digests of all of the field isolates). Plaque purified derivatives of FPV M showed similar lesion development upon inoculation into the wing web of chickens. The field isolates showed significantly higher virulence in day-old and three-week-old chickens in comparison with FPV M. One field isolate was similar to the FPV S vaccine. Two isolates had slowly developing wing web lesions, caused significant secondary lesions in three-week-old chickens and generalised poxvirus infection when inoculated into day-old chickens. For two isolates, the primary wing web lesion took even longer to develop and resolve although...Continue Reading

Citations

Mar 26, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·G IsaC P Czerny
Oct 25, 2002·Avian Pathology : Journal of the W.V.P.A·Luiz C B FallavenaAri B da Silva
Mar 23, 2000·Journal of Virology·C L AfonsoD L Rock
May 3, 2006·Veterinary Microbiology·Jianning WangWayne F Robinson
Oct 9, 2013·Avian Pathology : Journal of the W.V.P.A·J E Estrella-TecJ L Puerto-Nájera
Mar 29, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Theodros Tadese, Willie M Reed

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