PMID: 6536666Jan 1, 1984Paper

Comparison of filtration to continuous-flow centrifugation for plasma exchange

Journal of Clinical Apheresis
L WoodP Jacobs

Abstract

The Asahi Plasmaflo Hollow Nylon Fibre Filtration System (n = 13) was directly compared to the NCI-IBM 2990 Continuous-Flow Blood Fraction Separator (n = 10) for plasma exchange. The systems were equally efficient in achieving plasma separation. There were significant differences favouring filtration for clearance of fibrinogen (P less than 0.05), and the fourth component of complement (P less than 0.01). Greater loss of urea (P less than 0.05) was found after plasma exchange, using the cell separator. The flow characteristics were markedly different. In a standardised 4-L plasma exchange, filtration took place at 35 ml/minute, with a procedure time of 109 +/- 45 minutes in contrast to centrifugation at a plasma flow collection rate of 19 ml/minute, requiring 208 +/- 17 minutes. This time advantage for the former procedure was offset by 195 minutes required to regenerate the hollow nylon fibre unit and a further 90 minutes required for cleaning under strictly controlled aseptic techniques prior to reuse. Each filter was regenerated at least twice and reused without infection, but there was incremental loss of filtration efficiency demonstrated by decreasing clearance of an intravascular marker dye. In two of the 13 procedures u...Continue Reading

References

Dec 1, 1978·The Journal of Pediatrics·R H McLeanN Rothfield
Jan 1, 1979·Clinical and Laboratory Haematology·R M RowanG A McDonald
Feb 10, 1979·The Medical Journal of Australia·P F RyanB G Firkin
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Jan 1, 1981·Annals of Neurology·M C Dalakas, W K Engel

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Citations

Dec 15, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Sanjeev BawejaLawrence P McMahon
Jan 1, 1990·Intensive Care Medicine·P M Reimann, P D Mason
Jan 1, 1985·Journal of Clinical Apheresis·L Wood, P Jacobs
Feb 2, 2017·Journal of Clinical Apheresis·Aurélie LemaireEmmanuel Canet

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