Comparison of final heights of growth hormone-treated vs. untreated children with idiopathic growth failure

The Journal of Clinical Endocrinology and Metabolism
J G BuchlisM H MacGillivray

Abstract

We measured adult heights (Ht) of 94 healthy GH-sufficient children (peak GH > 10 ng/mL, polyclonal RIA) whose Ht at presentation were more than 2 SD below the mean for chronological age, with normal weight-to-Ht ratios, normal body proportions, and pathologic growth velocity for chronological age. Group 1 (n 36, 6 females) received standardized doses (0.3 mg/kg x week) of GH (mean duration = 41 months), while group 2 (n = 58, 17 females) received no treatment. Our conclusion was that the mean final Ht SD score in the GH-treated group (-1.5) was significantly greater than in the untreated group (-2.1); P < .001. Genetic predisposition to short stature was evident in both groups: the midparental Ht SD score was -1.1 in the treated and -1.0 in the untreated group. Midparental Ht was met or exceeded by 42% of the GH-treated group but only 15% of the untreated group. Final Ht was not significantly different from predicted Ht, except from GH-treated girls, who exceeded their predicted Ht. Although the mean Ht gains (6.8 cm in girls and 3 cm in boys) were modest and variable, GH treatment provided significantly better Ht outcomes for the majority of children with idiopathic growth failure.

References

Mar 1, 1979·The American Journal of Clinical Nutrition·P V HamillW M Moore
Aug 1, 1991·European Journal of Pediatrics·E C CrowneD A Price
Oct 1, 1990·Archives of Disease in Childhood·E C CrowneD A Price
Dec 1, 1990·Pediatric Clinics of North America·J F Cara, A J Johanson
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·M B Ranke, A S Aronson
Feb 17, 1989·JAMA : the Journal of the American Medical Association·J LantosL Cuttler
Oct 27, 1983·The New England Journal of Medicine·G Van VlietM M Grumbach
Jul 16, 1981·The New England Journal of Medicine·D RudmanJ H Patterson
Aug 1, 1995·European Journal of Pediatrics·M SperlichH P Schwarz
May 1, 1994·Journal of Clinical Nursing·B Price
Apr 1, 1993·European Journal of Pediatrics·A Albanese, R Stanhope
Feb 15, 1996·The New England Journal of Medicine·Y TakahashiK Chihara
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·S L BlethenA Johanson

❮ Previous
Next ❯

Citations

Jul 16, 2010·Biologics : Targets & Therapy·J Paul Frindik, Stephen F Kemp
Jan 8, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J M WitP Cohen
Mar 6, 2007·Endocrinology and Metabolism Clinics of North America·Charmian A Quigley
Jul 31, 2014·International Journal of Pediatric Endocrinology·Juan F Sotos, Naomi J Tokar
Jan 31, 2002·Paediatric Drugs·Ameeta Mehta, Peter C Hindmarsh
Mar 4, 2005·Treatments in Endocrinology·Roberto Lanes
Apr 24, 2013·Nature Reviews. Endocrinology·Michael B Ranke
Feb 18, 1999·The Journal of Clinical Endocrinology and Metabolism·A M PasquinoF Cerrone
Jan 19, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Lucia SchenaMauro Bozzola
May 9, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Hwal Rim JeongJin Soon Hwang
May 13, 2005·Journal of Endocrinological Investigation·S LocheM Cappa
Jan 30, 2007·Annals of Saudi Medicine·Abdelaziz Elamin, A Tuvemo
Mar 11, 2005·Indian Journal of Pediatrics·Anurag Bajpai, P Sn Menon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.