Comparison of finasteride versus spironolactone in the treatment of idiopathic hirsutism

Fertility and Sterility
M ErenusO Gürbüz

Abstract

To compare the efficacy of finasteride and spironolactone in the treatment of idiopathic hirsutism. Prospective, randomized, single-blind study. A tertiary hirsutism clinic. Forty women with idiopathic hirsutism were selected. Patients were assigned randomly to receive either 5 mg of finasteride or 100 mg of spironolactone for 9 months. Hirsutism scores were measured according to the Ferriman-Gallwey scoring system, and side effects were monitored for 9 months of treatment. Blood samples were taken at each visit for assessment of endocrine, biochemical, and hematologic parameters. Hirsutism scores were decreased significantly in both groups at the end of 9 months. The mean percent change (+/- SD) in hirsutism scores in the finasteride and spironolactone groups was as follows: 5.91% +/- 7.18% and 20.60% +/- 12.59% at 3 months, 10.61% +/- 12.18% and 32.57% +/- 15.68% at 6 months, and 15.15% +/- 15.38% and 42.36% +/- 12.31% at 9 months, respectively. There was a significantly better response with spironolactone treatment at the end of 9 months. Eleven (55%) of 20 patients in the spironolactone group experienced side effects. However, none of them stopped treatment because of side effects. The present data suggest that both finaste...Continue Reading

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