PMID: 15361722Sep 14, 2004Paper

Comparison of five-day cefdinir treatment with ten-day low dose amoxicillin/clavulanate treatment for acute otitis media

The Pediatric Infectious Disease Journal
Stan L BlockStanley Bukofzer

Abstract

Short course beta-lactam antibiotic therapy for acute otitis media (AOM) should improve patient adherence, but it has not been evaluated since the heptavalent pneumococcal conjugate vaccine became routinely used in the United States. In a prospective, investigator-blinded, multicenter study, 425 patients, age 6 months-6 years, with a clinical diagnosis of nonrefractory AOM were randomized to receive either 5 days of cefdinir therapy (14 mg/kg divided twice daily) or 10 days of amoxicillin/clavulanate therapy (45/6.4 mg/kg divided twice daily). Clinical response was assessed at end of therapy (2-4 days postantibiotic, respectively) and week 4 (study days 25-28). With no difference in demographics between treatment groups, overall the mean age (+/-SD) was 2.8 +/- 1.8 years, 65% had received conjugated pneumococcal vaccination and 48% had bilateral AOM. The satisfactory clinical response rate at end of therapy was comparable for cefdinir versus amoxicillin/clavulanate (88%, 170 of 194 versus 85%, 164 of 192; 95% CI -4.9, 9.3). Although this must be interpreted with caution, cefdinir showed an apparent trend for higher efficacy than amoxicillin/clavulanate (92%, 72 of 78 versus 77%, 55 of 71; P = 0.019) in a subsample of patients 6...Continue Reading

References

Jan 6, 2001·The Pediatric Infectious Disease Journal·S L BlockK J Tack
Jan 6, 2001·The Pediatric Infectious Disease Journal·S L BlockUNKNOWN Cefdinir Otitis Media Study Group
Feb 15, 2001·The New England Journal of Medicine·J EskolaUNKNOWN Finnish Otitis Media Study Group
Feb 15, 2001·The Pediatric Infectious Disease Journal·R W SteeleR E Bégué
Dec 6, 2001·The Pediatric Infectious Disease Journal·R DaganM R Jacobs
Apr 1, 2003·Journal of Interventional Cardiology·Peter C Block
Sep 14, 2004·The Pediatric Infectious Disease Journal·Janet R Casey, Michael E Pichichero

❮ Previous
Next ❯

Citations

Sep 14, 2004·The Pediatric Infectious Disease Journal·Stephen I Pelton
Feb 3, 2007·Expert Review of Anti-infective Therapy·Helio S Sader, Ronald N Jones
May 26, 2006·Expert Opinion on Pharmacotherapy·James A Hadley
Apr 26, 2006·Expert Opinion on Emerging Drugs·Avner AliphasKenneth M Grundfast
Apr 11, 2008·International Journal of Pediatric Otorhinolaryngology·Michael E Pichichero, Janet R Casey
Mar 14, 2007·Diagnostic Microbiology and Infectious Disease·Stan L BlockMichael A Pfaller
Nov 17, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Masatoshi KonnoKimiko Ubukata
Nov 17, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Masatoshi KonnoKimiko Ubukata
Feb 28, 2007·Clinical Pediatrics·Stephanie M ChandlerDavid P McCormick
Sep 9, 2010·The Cochrane Database of Systematic Reviews·Anita KozyrskyjKrystal Harvey
May 13, 2015·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Jemima KuehnMike Sharland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.