Comparison of five different hormonal treatment protocols for children with cryptorchidism

Scandinavian Journal of Urology and Nephrology
Ciro EspositoAlessandro Settimi

Abstract

To compare the effects of medical therapy on boys with cryptorchidism, a prospective study was carried out in five groups of patients over a 30-month period. A total of 439 boys with undescended testicles were enrolled; their ages ranged between 6 months and 13 years (median 4.2 years). Of these, 327 had true unilateral and 112 bilateral undescended testicles. In 115 patients surgery was performed directly either because the condition was associated with inguinal hernia or because the child had undergone previous inguinal surgery; hormonal treatment was attempted in the remaining 324 patients. Human chorionic gonadotrophin (hCG) was administered to 113 patients (34.8%), luteinizing hormone-releasing hormone (LH-RH) to 85 (26.2%), a combination of LH-RH and hCG to 64 (19.7%), human menopausal gonadotrophin (hMG) to 35 (10.8%) and a combination of hMG and hCG to 27 (8.3%). Overall, testicular descent was achieved in 27.7% (90/324) of patients: specifically, in 38.2% (36/94) of boys with bilateral undescended testicles (both testes in 22/36, one testis only in 14/36) but in only 23.4% (54/230) of those with unilateral undescended testicles (p = 0.007). The correlation between the type of therapy and testicular descent can be summa...Continue Reading

References

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Citations

Jul 31, 2007·BJU International·Dragana ZivkovicFaruk Hadziselimovic
Apr 28, 2007·Acta Paediatrica·Arni V ThorssonMartin Ritzén
Jul 15, 2005·Expert Opinion on Pharmacotherapy·Alan D Rogol
Jan 11, 2007·Seminars in Pediatric Surgery·John M Hutson, Melanie C C Clarke

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