PMID: 20650085Jun 1, 1995Paper

Comparison of five potential methods for assessing ocular irritation in vitro

Toxicology in Vitro : an International Journal Published in Association with BIBRA
L K EarlK A O'Brien

Abstract

Thirty-three test substances comprising household and personal products and a pure surfactant were used in an independent evaluation of the ability of five selected in vitro assays to predict eye irritation potential. The data were compared with historical archived data from rabbit eye irritation tests conducted on the same subsamples. The data were assessed in three ways. The linear correlation for all 33 test substances with in vivo data was poor for each assay. However, the correlation improved greatly for some assays when a group of similar test substances was considered. Analysis of the data by Cooper's criteria suggested that fluorescein diacetate uptake by Chinese hamster V79 cells (V79) and the Microtox test kit were the best of the assays evaluated in discriminating correctly between the irritants and non-irritants that were identified by rabbit eye irritation testing. Some of the data were selected for further analysis because it was possible to predict differences, based on experience learned from animal data on similar substances, between the test substances without reference to experimental data. Neat or more concentrated test substances were predicted to be more irritant than dilutions and an experimental laundry ...Continue Reading

References

Jul 1, 1991·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·L H BrunerR D Parker
Aug 1, 1981·Food and Cosmetics Toxicology·A B BurtonR S Lawrence
Apr 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K A O'BrienM Dixit
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K A O'BrienJ Rockley
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·V C GordonH C Bergman
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R H Clothier, M Balls
Jan 1, 1991·Toxicology in Vitro : an International Journal Published in Association with BIBRA·O BleinK G Dossou
Nov 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K A O'BrienR W Lewis

❮ Previous
Next ❯

Citations

Aug 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L GilleronP Vanparys
Jul 8, 2008·Regulatory Toxicology and Pharmacology : RTP·Montserrat MitjansM Pilar Vinardell
Mar 19, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sandra VerstraelenPhilippe Vanparys
May 9, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Susan M O'MearaNicky A Cullum
Apr 10, 2010·Alternatives to Laboratory Animals : ATLA·Arnhild SchrageRobert Landsiedel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Toxicology in Vitro : an International Journal Published in Association with BIBRA
R J Soto, V C Gordon
Toxicology in Vitro : an International Journal Published in Association with BIBRA
P D GautheronHorst Spielmann
Toxicology in Vitro : an International Journal Published in Association with BIBRA
T HayashiS Kato
Toxicology in Vitro : an International Journal Published in Association with BIBRA
V C GordonH C Bergman
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M P VinardellM Mitjans
© 2021 Meta ULC. All rights reserved