Comparison of Fixed-Dose Inhaled Epoprostenol and Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome in Critically Ill Adults.

Journal of Intensive Care Medicine
Mitchell S BuckleyRobert MacLaren

Abstract

Several reports have demonstrated similar effects on oxygenation between inhaled epoprostenol (iEPO) compared to inhaled nitric oxide (iNO) for acute respiratory distress syndrome (ARDS). Previous studies directly comparing oxygenation and clinical outcomes between iEPO and iNO exclusively in an adult ARDS patient population utilized a weight-based dosing strategy. The purpose of this study was to compare the clinical and economic impact between iNO and fixed-dosed iEPO for ARDS in adult intensive care unit (ICU) patients. This retrospective cohort study was conducted at a major academic medical center between January 1, 2014, and October 31, 2018. Patients ≥18 years of age with moderate-to-severe ARDS were included. The primary end point was to compare the mean change in partial arterial oxygen pressure to fraction of inspired oxygen (Pao 2: Fio 2) at 4 hours from baseline between iEPO and iNO. Other secondary aims were total acquisition drug costs, in-hospital mortality, ICU and hospital length of stay, and duration of mechanical ventilation. A total of 239 patients were included with 139 (58.2%) and 100 (41.8%) in the iEPO and iNO groups, respectively. The mean change in Pao 2: Fio 2 at 4 hours from baseline in the iEPO and ...Continue Reading

References

Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·D WalmrathW Seeger
Aug 16, 2005·Chest·Renee D StapletonKenneth P Steinberg
Jun 26, 2010·Pharmacotherapy·Mitchell S Buckley, Jeremy P Feldman
May 21, 2013·Journal of Critical Care·Heather TorbicGerald Weinhouse
Mar 21, 2015·Intensive Care Medicine·Daniel Brodie, Claude Guérin
Jul 19, 2015·The Annals of Pharmacotherapy·Mahmoud A AmmarSimon W Lam
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Giacomo BellaniUNKNOWN ESICM Trials Group
Sep 15, 2017·Annals of the American Thoracic Society·Erick H DuanUNKNOWN Canadian Critical Care Trials Group
Feb 22, 2018·JAMA : the Journal of the American Medical Association·Eddy FanArthur S Slutsky
Apr 29, 2018·Journal of Cardiothoracic and Vascular Anesthesia·Salvatore SardoLudhmila Abrahao Hajjar
Feb 23, 2019·Journal of Pharmacy Practice·Mitchell S BuckleyJeffrey P Gonzales
Jun 15, 2019·Annals of Intensive Care·Laurent PapazianHenri Faure
Jul 2, 2019·BMJ Open Respiratory Research·Mark J D GriffithsSimon V Baudouin

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Citations

Nov 26, 2020·Journal of Intensive Care Medicine·Rajiv SontiNathan Cobb
Feb 18, 2021·Minerva anestesiologica·Alessia LongobardoNishkantha Arulkumaran

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