PMID: 6105907Jul 1, 1980Paper

Comparison of flunitrazepam and thiopentone for induction of general anaesthesia

Canadian Anaesthetists' Society Journal
J R MaltbyR Phillips

Abstract

Forty female out-patients undergoing therapeutic abortion participated in a double-blind study comparing flunitrazepam 0.05 mg . kg-1 with thiopentone 6.0 mg . kg-1 as induction agents for general anaesthesia. Induction time, as measured by the time to loss of lid reflex and voluntary speech, was not only significantly longer in patients receiving flunitrazepam, but also much more variable and imprecise than with thiopentone. The Steward recovery room scores and psychomotor drawing test results revealed that recovery was significantly slower in the flunitrazepam group. Anterograde amnesia was observed in all patients who had received flunitrazepam and in one patient who had received thiopentone. No retrograde amnesia was found in either group. Flunitrazepam produced postoperative drowsiness, sedation, ataxia and nausea while with thiopentone discomfort from surgery and discomfort at the intravenous injection site were the main complaints. Because of the slowness of induction with flunitrazepam and marked individual variation, we do not feel that this drug can be considered a suitable agent for routine induction of general anaesthesia.

References

Jun 1, 1976·British Journal of Anaesthesia·J W DundeeR S Clarke
Jan 1, 1977·Acta Anaesthesiologica Scandinavica·R S Clarke, S M Lyons
Oct 1, 1977·British Journal of Anaesthesia·M A MattilaK Säilä
Mar 1, 1978·British Journal of Anaesthesia·K KorttilaM Hytönen
Jul 1, 1979·British Journal of Anaesthesia·J W Dundee
Jan 1, 1975·Canadian Anaesthetists' Society Journal·D J Steward
Jan 1, 1972·Psychopharmacologia·M SchulerR Tissot
Jan 1, 1973·Acta Anaesthesiologica Scandinavica·J StovnerA Osterud
Jan 1, 1969·Anesthesia and Analgesia·M G NewmanJ C Miller

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Citations

Nov 14, 2014·CNS Drugs·J van GaalenB P C van de Warrenburg
Feb 17, 2006·Extremophiles : Life Under Extreme Conditions·Anna DerekovaMargarita Kambourova
Jan 9, 2008·Journal of Evolutionary Biology·R Bshary, R Bergmüller
Dec 18, 2015·Proceedings. Biological Sciences·Bruno A BuzattoJoseph L Tomkins
Apr 2, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Bruno A BuzattoJoseph L Tomkins
Jan 5, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Eric Alden Smith
May 31, 2018·Pharmaceuticals·Dorota OlenderLucjusz Zaprutko

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