Comparison of four cisplatin-based radiochemotherapy regimens for nonmetastatic stage III/IV squamous cell carcinoma of the head and neck

International Journal of Radiation Oncology, Biology, Physics
Dirk RadesJuergen Dunst

Abstract

To compare the outcomes of four cisplatin-based radiochemotherapy regimens in 311 patients with Stage III/IV squamous cell carcinoma of the head and neck. Concurrent chemotherapy consisted of three courses of cisplatin 100 mg/m(2) on Day 1 (Group A, n = 74), two courses of cisplatin 20 mg/m(2) on Days 1-5 plus 5-fluorouracil 1,000 mg/m(2) on Days 1-5 (Group B, n = 49), two courses of cisplatin 20 mg/m(2) on Days 1-5 plus 5-fluorouracil 600 mg/m(2) on Days 1-5 (Group C, n = 102), or two courses of cisplatin 20 mg/m(2) on Days 1-5 (Group D, n = 86). The groups were retrospectively compared for toxicity and outcomes, and 11 additional factors were evaluated for outcomes. No significant difference was observed among the groups regarding radiation-related acute oral mucositis and radiation-related late toxicities. Acute Grade 3 skin toxicity was significantly more frequent in Group B than in the patients of the other three groups (p = .013). The chemotherapy-related Grade 3 nausea/vomiting rate was 24% for Group A, 8% for Group B, 9% for Group C, and 6% for Group D (p = .003). The corresponding Grade 3 nephrotoxicity rates were 8%, 1%, 2%, and 1% (p = .019). The corresponding Grade 3-4 hematologic toxicity rates were 35%, 41%, 19%, ...Continue Reading

References

Mar 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M B BartonE Maki
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·D W Bruner, T Wasserman
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·D L KwongP M Wu
Feb 8, 2000·International Journal of Radiation Oncology, Biology, Physics·A BeckerJ Dunst
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·A TrottiW Curran
Oct 18, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·V RudatA Dietz
Oct 10, 2001·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·V RudatH J Feldmann
Feb 23, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V BudachJ C Horiot
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David J AdelsteinArlene A Forastiere
May 7, 2004·The New England Journal of Medicine·Jay S CooperUNKNOWN Radiation Therapy Oncology Group 9501/Intergroup
May 7, 2004·The New England Journal of Medicine·Jacques BernierUNKNOWN European Organization for Research and Treatment of Cancer Trial 22931
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Branislav JeremicLjiljana Tadic

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Citations

Nov 23, 2011·International Journal of Radiation Oncology, Biology, Physics·Giuseppe SanguinetiArlene Forastiere
Sep 3, 2011·Australian Dental Journal·H DengR M Logan
Aug 9, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Dirk RadesSteven E Schild
Oct 1, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Dirk RadesSteven E Schild
Mar 23, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Christie G RegulaNaomi Lawrence
Jul 30, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Michael A RenziNaomi Lawrence
Jul 30, 2017·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A Al-MamganiM E Tesselaar
Aug 31, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M LapeyreP Graff-Cailleaud

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