PMID: 2091902Aug 1, 1990Paper

Comparison of four different methods for detection of Helicobacter pylori from gastric biopsies

Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi = Chinese Journal of Microbiology and Immunology
N LeeK M Fang

Abstract

Helicobacter pylori are commonly found colonizing the gastric mucosa of different populations. Its presence may be important in the pathogenesis of gastritis and peptic ulcer disease. The detection rates vary widely depending upon the diagnostic methods applied. In this study, multiple gastric biopsies were taken from the fundal and antral mucosa of 25 patients during endoscopy. In one patient, the procedure was repeated about two months after the initial biopsy. A total of 52 sets of specimens were obtained. One sample from each site was used to make imprint smear and tissue section. The other sample was used for microbiological culture and rapid urease test. An association between histological confirmed chronic gastritis (both active and inactive) and the morphological diagnosis of H. pylori by tissue sections was found in all of the 26 cases (52 specimens). There was an excellent concordance (96.2%) between the morphological diagnosis of H. pylori in the Gram-stained imprint smears and the tissue sections. There was a good concordance (86.5%) between the histology and the bacterial culture. Interestingly, a different species of gastric campylobacter-like organism with similar morphological appearance was also cultivated. The...Continue Reading

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