Comparison of Fractional FLow Reserve And Intravascular ultrasound-guided Intervention Strategy for Clinical OUtcomes in Patients with InteRmediate Stenosis (FLAVOUR): Rationale and design of a randomized clinical trial

American Heart Journal
Jeehoon KangSeung-Jae Tahk

Abstract

Coronary angiography has limitations in defining the ischemia-causing stenotic lesion, especially in cases with intermediate coronary stenosis. Fractional flow reserve (FFR) is a current standard method to define the presence of ischemia, and intravascular ultrasound (IVUS) is the most commonly used invasive imaging tool that can provide the lesion geometry and can provide the information on plaque vulnerability. The primary aim of this study is to compare the safety and efficacy of FFR-guided and IVUS-guided percutaneous coronary intervention (PCI) strategies in patients with intermediate coronary stenosis. Comparison of Fractional FLow Reserve And Intravascular ultrasound-guided Intervention Strategy for Clinical OUtcomes in Patients with InteRmediate Stenosis (FLAVOUR) trial is an international, multicenter, prospective, randomized clinical trial. A total of 1,700 consecutive patients with intermediate stenosis (40%-70% by visual estimation) in a major epicardial coronary artery will be randomized 1:1 to receive either FFR-guided or IVUS-guided PCI strategy. Patients will be treated with PCI according to the predefined criteria for revascularization; FFR ≤ 0.80 in the FFR-guided group and Minimal Lumen Area (MLA) ≤3 mm2 (or ...Continue Reading

References

May 1, 1984·Journal of the American College of Cardiology·N TraskG S Wagner
Mar 19, 2003·Zeitschrift für Kardiologie·Evelyn Regar, Patrick W Serruys
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
May 29, 2007·Journal of the American College of Cardiology·Nico H J PijlsBernard de Bruyne
Mar 20, 2010·JACC. Cardiovascular Interventions·Narbeh MelikianBernard De Bruyne
May 7, 2010·The New England Journal of Medicine·Gregg W StoneUNKNOWN SPIRIT IV Investigators
Dec 4, 2010·Circulation·William F FearonUNKNOWN Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) Study Investigators
Jan 21, 2011·The New England Journal of Medicine·Gregg W StoneUNKNOWN PROSPECT Investigators
Feb 7, 2012·Circulation·Lisette Okkels JensenUNKNOWN Scandinavian Organization for Randomized Trials With Clinical Outcome IV (SORT OUT IV) Investigators
Jul 21, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hae-Geun SongSeung-Jung Park
Oct 20, 2012·JACC. Cardiovascular Interventions·Seung-Jung ParkSeong-Wook Park
Nov 23, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Yaojun ZhangShao-Liang Chen
Feb 26, 2013·The American Journal of Cardiology·Soo-Jin KangSeung-Jung Park
Feb 18, 2014·JACC. Cardiovascular Interventions·Jae-Sik JangDong-Soo Kim
Sep 2, 2014·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
Nov 12, 2015·JAMA : the Journal of the American Medical Association·Sung-Jin HongUNKNOWN IVUS-XPL Investigators
Nov 17, 2015·Heart Failure Clinics·Elliott M GrovesMorton J Kern
Nov 15, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Nitesh NerlekarAdam J Brown
Nov 24, 2016·The American Journal of Cardiology·Shinji InabaAkiko Maehara
Mar 21, 2017·The New England Journal of Medicine·Matthias GötbergUNKNOWN iFR-SWEDEHEART Investigators
Mar 21, 2017·The New England Journal of Medicine·Justin E DaviesJavier Escaned
Apr 26, 2017·Coronary Artery Disease·Gary S Mintz

❮ Previous
Next ❯

Citations

Nov 12, 2019·European Journal of Internal Medicine·Masatake KobayashiJoão Pedro Ferreira
Nov 9, 2021·Frontiers in Cardiovascular Medicine·Jun-Mei ZhangLiang Zhong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.