Comparison of frequency of inflammatory bowel disease and noninfectious gastroenteritis among statin users versus nonusers

The American Journal of Cardiology
Dina KhalilIshak A Mansi

Abstract

Conflicting data exist regarding the effects of statin therapy on the prevalence of inflammatory bowel diseases. We aimed to examine the association of statin therapy with diagnoses of inflammatory bowel diseases and noninfectious gastroenteritis. This is a retrospective study using data of a military health care system from October 1, 2003, to March 1, 2012. Based on medication fills during fiscal year 2005, patients were divided into: (1) statin users (received at least 90-day supply of statin) and (2) nonusers (never received a statin). A propensity score-matched cohort of statin users and nonusers was created using 80 variables. Primary analysis examined the risks of being diagnosed with inflammatory bowel diseases and noninfectious gastroenteritis between statin users and nonusers in the propensity score-matched cohort. Secondary analyses examined the risk of outcomes in the whole cohort and in patients with no comorbidities according to Charlson Comorbidity Index. Of 43,438 patients meeting study criteria (13,626 statin users and 29,812 nonusers), we propensity score matched 6,342 statin users with 6,342 nonusers. For our primary analysis, 93 statin users and 92 nonusers were diagnosed with inflammatory bowel diseases (od...Continue Reading

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Citations

Jan 9, 2016·The American Journal of Cardiology·Tushar AcharyaIshak A Mansi
Jun 23, 2015·Pharmacoepidemiology and Drug Safety·Ricardo BadilloIshak Mansi
Dec 8, 2016·The American Journal of Gastroenterology·Cong DaiMing-Jun Sun
Dec 8, 2016·The American Journal of Gastroenterology·Ryan UngaroJean-Frederic Colombel
Jan 26, 2016·Inflammatory Bowel Diseases·Justin Côté-DaigneaultJean-Frédéric Colombel
Dec 23, 2020·Journal of Crohn's & Colitis·Cong DaiYu-Hong Huang
Jan 22, 2021·Journal of Crohn's & Colitis·Paul LochheadJonas F Ludvigsson
Aug 12, 2021·Therapeutic Advances in Gastroenterology·Jasmijn A M SleutjesAnnemarie C de Vries

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