Comparison of frozen section and touch imprint cytology for evaluation of sentinel lymph node metastasis in breast cancer

Annals of Surgical Oncology
Tomohiko AiharaYuichi Takatsuka

Abstract

Sentinel lymph node metastasis of breast cancer is evaluated by frozen section (FS) or touch imprint cytology (TIC). However, which of the two methods is superior remains controversial. Here we directly compared the sensitivity of these methods prospectively. The study included 208 SNs harvested from 107 consecutive patients with breast cancer who underwent sentinel lymph node biopsy. SNs were serially sectioned at 2-mm intervals, and two sections were subjected to intraoperative evaluation of FS with hematoxylin and eosin staining. TIC specimens were prepared from all cut surfaces and analyzed by Papanicolaou (TIC) and cytokeratin (TIC with immunohistochemistry; TIHC) immunohistochemistry. Thirty-five SNs from 27 patients were positive by final histopathology. The sensitivity per sentinel lymph node of FS was 89%; it was 86% for TIC and 89% for TIHC. Among 173 negative SNs, the results of FS were concordant with final histopathology, but TIC and TIHC were positive in 1 and 5 histopathology-negative SNs, respectively. The sensitivity per patient of FS was 85%; it was 85% for TIC and 89% for TIHC. Among 80 patients with node-negative disease, the results of FS and TIC were concordant with final histopathology, whereas TIHC was p...Continue Reading

References

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Citations

Apr 7, 2009·Annals of the Royal College of Surgeons of England·Alireza Hamidian JahromiGerald Gui
Sep 20, 2007·Annals of Surgical Oncology·Nimmi AroraRache M Simmons
Jun 23, 2010·Annals of Surgical Oncology·Jan P KamińskiEdward A Levine
May 20, 2008·Surgical Oncology Clinics of North America·Lucio FortunatoCarlo Eugenio Vitelli
Jul 22, 2008·Journal of Photochemistry and Photobiology. B, Biology·Kaustuv DasNicholas Stone
Jan 4, 2008·Pathology, Research and Practice·Pauline AthanassiadouEfstratios Patsouris
Jun 5, 2007·Journal of Comparative Pathology·R HöinghausR Mischke
May 28, 2009·Histopathology·Anthony G Douglas-Jones, Victoria Woods
Oct 24, 2012·ANZ Journal of Surgery·Angela D M RichardsOwen A Ung
Aug 6, 2013·International Journal of Cancer. Journal International Du Cancer·Ryota OtsuboTakeshi Nagayasu
Mar 10, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I-K LeeY H Ryu
Feb 1, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F CelebiogluJ Frisell
Aug 17, 2016·Tissue & Cell·Monjoy SahaChandan Chakraborty
Sep 6, 2006·The Breast : Official Journal of the European Society of Mastology·N A QureshiA R Carmichael
Jun 29, 2007·Journal of the National Cancer Institute·Deirdre P Cronin-FentonBrenda K Edwards
Oct 15, 2005·Current Opinion in Oncology·Ann Smeets, Marie-Rose Christiaens
Dec 6, 2005·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Young-Joon LeeWoo-Song Ha
Feb 11, 2015·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hitoshi Tsuda

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