Comparison of functional fibrinogen (FF/CFF) and FIBTEM in surgical patients - a retrospective study

Clinical Chemistry and Laboratory Medicine : CCLM
Florian PrüllerHarald Mangge

Abstract

Fibrinogen-based clot firmness is reported as the maximum amplitude (MA) when using the citrated functional fibrinogen (CFF) assay in thrombelastography (TEG), and as the maximum clot firmness (MCF) together with several clot amplitude parameters when using the FIBTEM assay in thromboelastometry (ROTEM). Concern is currently being raised that these two tests have different platelet inhibiting performance and consequently provide different values. This is relevant for the clinical setting of fibrinogen replacement. We aim herein to compare the parameters of these two fibrinogen-based clot quality tests and their correlation with the plasma fibrinogen level as determined by the Clauss method. In total 261 whole blood samples taken from 163 clinical routine surgical patients were analyzed with TEG 5000 and ROTEM tests, and correlation with Clauss fibrinogen level was assessed. Using TEG, the overall fibrin-based clot firmness measured in the CFF assay was significantly higher than the MCF measured by FIBTEM assay. Both assays showed significantly positive correlations with the fibrinogen levels measured using the Clauss method. However, individual values of Clauss fibrinogen concentration corresponded with different values for the...Continue Reading

References

Oct 1, 1974·Journal of Insect Physiology·H J Meyer, D M Norris
Sep 23, 2003·QJM : Monthly Journal of the Association of Physicians·S Kamath, G Y H Lip
May 5, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Thomas LangMeret Lakner
Feb 15, 2007·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnUNKNOWN Task Force for Advanced Bleeding Care in Trauma
Apr 7, 2007·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G Nielsen
May 1, 2007·Critical Care : the Official Journal of the Critical Care Forum·Michael Eisenhut
Aug 30, 2008·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·David Della MorteFranco Rengo
Jan 16, 2009·Anaesthesia·G N B JacksonS M Yentis
Apr 8, 2010·Critical Care : the Official Journal of the Critical Care Forum·Rolf RossaintUNKNOWN Task Force for Advanced Bleeding Care in Trauma
Jan 8, 2011·Journal of Thrombosis and Haemostasis : JTH·Y Ozier, B J Hunt
Mar 1, 2012·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Herbert SchöchlWolfgang Voelckel
Mar 31, 2012·The Western Journal of Emergency Medicine·Zachary LevyHeather Farley
May 31, 2012·Journal of Thrombosis and Thrombolysis·Giuseppe LippiMassimo Franchini
Mar 28, 2013·World Journal of Emergency Surgery : WJES·Ajith SankarankuttySandro Rizoli
Apr 23, 2013·The Breast : Official Journal of the European Society of Mastology·Nancy U LinUNKNOWN European School of Oncology-Metastatic Breast Cancer Task Force
May 11, 2013·Transfusion·Benno von BormannRolf Zander
Jul 9, 2013·Transfusion·Øivind JansUNKNOWN Lundbeck Foundation Centre for Fast-track Hip and Knee Replacement Collaborative Group
Oct 15, 2013·American Journal of Hematology·David Whiting, James A DiNardo
Feb 11, 2014·The Annals of Thoracic Surgery·Katarina WaldénMartin Karlsson
May 2, 2014·Anesthesia and Analgesia·Anna AgrenGustaf Edgren
Dec 17, 2014·The Journal of Surgical Research·Martin A S MeyerJakob Stensballe
Dec 19, 2014·Blood·Jerrold H Levy, Lawrence T Goodnough

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Citations

Jul 28, 2016·International Journal of Obstetric Anesthesia·J H Bamber
Aug 4, 2016·Perfusion·Wiebe J de BoerYuri M Ganushchak
Oct 22, 2019·Minerva anestesiologica·Tetsuro Sakai
Jul 3, 2019·American Journal of Clinical Pathology·Amy E SchmidtMajed A Refaai
Jun 4, 2019·BMC Anesthesiology·Alessandra SpasianoGiorgio Della Rocca
Nov 4, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Harry MaguniaAndreas Straub

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Software Mentioned

FIBTEM
PASW Statistics

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