Comparison of fusion imaging using a combined SPECT/CT system and intra-arterial CT: assessment of drug distribution by an implantable port system in patients undergoing hepatic arterial infusion chemotherapy

Cardiovascular and Interventional Radiology
Osamu IkedaKeiichiro Kanemitsu

Abstract

Hepatic arterial infusion (HAI) chemotherapy is effective for treating primary and metastatic carcinoma of the liver. We compared the perfusion patterns of HAI chemotherapy on intra-arterial port-catheter computed tomography (iapc-CT) and fused images obtained with a combined single-photon emission computed tomography/computed tomography (SPECT/CT) system. We studied 28 patients with primary or metastatic carcinoma of the liver who bore an implantable HAI port system. All underwent abdominal SPECT using Tc-99m-MAA (185 Mbq); the injection rate was 1 mL/min, identical to the chemotherapy infusion rate, and 0.5 mL/sec for iapc-CT. Delivery was through an implantable port. We compared the intrahepatic perfusion (IHP) and extrahepatic perfusion (EHP) patterns of HAI chemotherapy on iapc-CT images and fused images obtained with a combined SPECT/CT system. In 23 of 28 patients (82%), IHP patterns on iapc-CT images and fused images were identical. In 5 of the 28 patients (18%), IHP on fusion images was different from IHP on iapc-CT images. EHP was seen on fused images in 12 of the 28 patients (43%) and on iapc-CT images in 8 patients (29%). In 17 patients (61%), upper gastrointestinal endoscopy revealed gastroduodenal mucosal lesions....Continue Reading

References

Jan 1, 1991·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M A PozniakD L Trump
Sep 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D C HohnB J Lewis
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Nov 18, 2003·Clinical Endocrinology·Yodphat KrauszOra Israel

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Citations

Jul 19, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Bohdan BybelManuel D Cerqueira
Dec 13, 2006·Seminars in Nuclear Medicine·Orazio SchillaciGiovanni Simonetti
Apr 9, 2008·Seminars in Nuclear Medicine·Youngho SeoBruce H Hasegawa

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