Abstract
Longitudinal changes in GAD antibody (Ab) and ICA512/IA-2 (ICA512) Ab were examined in relation to age at the onset of diabetes and autoimmunity against the thyroid gland. GADAb, ICA512Ab, and antithyroid autoantibody were examined at onset in 40 juvenile-onset IDDM patients (17 males, 23 females, age at onset 9.4 +/- 4.1 years, range 1.7-20). To assess the changes in antibody levels, 29 patients were followed up with sequential serum samples for up to 5 years. At onset, GADAb, ICA512Ab, and antithyroid autoantibody (thyroglobulinAb or thyroid peroxidaseAb) were found in 70, 58, and 25% of the 40 patients, respectively. Prepubertal patients (n = 21) had a significantly higher prevalence and index of ICA512Ab compared with pubertal patients (n = 19) (76 vs. 37%, P = 0.012, and 2.43 +/- 2.36 vs. 0.66 +/- 1.23, P = 0.011), while GADAb was more prevalent in pubertal patients (57 vs. 84%, P = 0.09). A longitudinal analysis of GADAb and ICA512Ab showed that GADAb levels declined more slowly than those of ICA512Ab (P = 0.008). Patients with continuous extremely high levels of GADAb also had high levels of antithyroid autoantibody. The measurement of ICA512Ab is useful in prepubertal patients, who often show rapid progression of the di...Continue Reading
Citations
May 7, 2009·Diabetologia·E H LiuD M Harlan
Nov 4, 2010·Diabetologia·L PiemontiE Bonifacio
Nov 13, 2001·Clinical and Experimental Immunology·C E De BlockUNKNOWN Belgian Diabetes Registry
Oct 29, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·T M DavisI R Mackay
Oct 19, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·C RattarasarnW Setasuban
Mar 5, 2003·Diabetes Technology & Therapeutics·William E WinterDesmond Schatz
May 18, 2005·Internal Medicine·Takashi NagaiMasatomo Mori
Aug 28, 2013·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Yuko ChibaAtsushi Araki
Nov 15, 2000·Autoimmunity·M OhtaN Itoh
Mar 30, 2000·Autoimmunity·B LindbergS A Ivarsson
Aug 19, 2008·Veterinary Immunology and Immunopathology·L J DavisonB Catchpole
Mar 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·L H DamanhouriI Todd
Mar 20, 2004·Scandinavian Journal of Immunology·A P M FernandesE A Donadi
Apr 30, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Tatsuhiko UrakamiHideo Mugishima
Feb 17, 2005·Diabetes Research and Clinical Practice·Ichiro YokotaUNKNOWN Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes
Jul 9, 2004·Biochemical and Biophysical Research Communications·Yih-Hsin ChangMichael S Lan
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·Kevan C Herold
May 24, 2015·Autoimmunity Reviews·Kostas KakleasKyriaki Karavanaki
Jan 1, 2008·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Tatsuhiko UrakamiHideo Mugishima
Nov 2, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M RodackiJ E P Oliveira
Dec 18, 1998·AACN Clinical Issues·N J Morwessel
Aug 24, 1999·The European Journal of Neuroscience·J M HermelM Solimena
Dec 25, 2003·Diabetes·Jerry P PalmerMichael W Steffes