Comparison of gastric, duodenal and jejunal contributions to the inhibition of food intake in the rat

Physiology & Behavior
R S Canbeyli, H S Koopmans

Abstract

Rats equipped with tubes leading to their stomach, duodenum or jejunum were infused with a liquid diet for 9 hr (4 ml/hr) and were allowed to eat during the last 8 hr of infusion. All rats ate significantly less on diet infusion days than on saline or no infusion days. A second study showed that a taste aversion could not be conditioned to flavored water associated with diet infusion. Apparently, intrajejunal injection of nutrients produces satiety and not discomfort. Infusion of the diet for 5 consecutive days into the stomach, duodenum or jejunum consistently and significantly lowered food intake by reducing meal size, not meal frequency. Results suggest that the small intestine below the infusion site contributes to normal satiety.

References

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Citations

Apr 1, 1989·Physiology & Behavior·P C GregoryD V Rayner
Nov 1, 1986·Journal of the Autonomic Nervous System·J Mélone
Jan 1, 1988·Nutrition Research Reviews·J M Forbes
May 11, 2013·Current Biology : CB·Adam P ChambersRandy J Seeley
Jul 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea L TracyT L Davidson
Nov 1, 1991·Psychological Medicine·P J HarrisonR C Pearson
Mar 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·R HunterG M Goodwin

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