Comparison of glomerular function tests in children with cancer.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Marika H GrönroosToivo T Salmi

Abstract

Evaluation of renal function should be performed as part of the follow-up during and after chemotherapy in pediatric cancer patients. The aim of this study was to compare an isotope clearance method [isotope glomerular filtration rate (iGFR)] with alternative methods to determine GFR in such patients. Isotope GFR [(99m)Tc-labeled diethylene triaminopentoacetic acid (DTPA) or (51)Cr-labeled ethylenediaminetetra-acetate (EDTA)] was measured in 36 children (112 studies) and compared with simultaneously measured creatinine clearance (CrCl), serum creatinine (SCr), and cystatin C (CysC) concentrations, as well as the results of Schwartz, Counahan-Barratt, and Cockroft-Gault formulae, using general linear mixed models. Our results showed a significant association between iGFR and CysC concentrations (p < 0.001). No linear relationship was observed between CrCl and iGFR (p = 0.7). As expected, the results of height-based formulae (Counahan-Barratt and Schwartz) had significantly (p = 0.004) better correlation to iGFR than the results of a formula based on weight (Cockroft-Gault) (p = 0.19). Despite significant linear correlation, intraclass correlation coefficients showed poor agreement. Tests of similarity between iGFR estimates show...Continue Reading

References

Dec 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A SuarezF Flamant
Jun 1, 1990·The Biochemical Journal·M AbrahamsonA Grubb
Mar 1, 1985·The Journal of Pediatrics·G J Schwartz, B Gauthier
Jul 1, 1995·Current Opinion in Oncology·R Skinner
May 6, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·R RossiJ H Ehrich
Aug 19, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E A YlinenM Knip
Jun 16, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·H FinneyC P Price
Jun 29, 2002·Journal of the American Academy of Nurse Practitioners·Mary Jo Goolsby
Oct 12, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lars HjorthDiana Karpman
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Elise WasénKerttu Irjala
Jul 16, 2003·Annals of Internal Medicine·Andrew S LeveyUNKNOWN National Kidney Foundation
Jul 20, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Edit BárdiCsongor Kiss
May 11, 2005·Kidney International·Guido FillerJochen H H Ehrich
Jan 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·George J Schwartz, Susan L Furth

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Citations

Jul 7, 2012·Journal of Pediatric Hematology/oncology·Paul GibsonAbha A Gupta
Mar 4, 2011·Pediatric Blood & Cancer·Lars HjorthDiana Karpman
Jun 20, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Benjamin L LaskinSonata Jodele
Oct 9, 2013·The Cochrane Database of Systematic Reviews·Sebastiaan L KnijnenburgMonique W M Jaspers
Mar 12, 2019·The Cochrane Database of Systematic Reviews·Esmee Cm KooijmansMargreet A Veening
Dec 7, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Penny WhitingUNKNOWN Cystatin C in Childhood Cancer Collaboration Group
Nov 28, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Arwa Nada, Jennifer G Jetton

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