Comparison of glucose and fat as energy sources in peripheral parenteral nutrition in rats

Journal of Nutritional Science and Vitaminology
Y FukutaY Kokuba


Glucose is usually chosen as the energy source for total parenteral nutrition. However, the optimal glucose:fat ratio for peripheral parenteral nutrition has not been examined sufficiently. We compared glucose:fat ratios in hypocaloric nutrition. Male SD rats were given hypocaloric parenteral nutrition (approx. 190 kcal/kg/d) for 5 d after laparotomy. The hypocaloric solutions used contained 0, 33, 50, 67 or 100% of the non-protein energy in the form of fat. Body weight change, nitrogen balance, organ weights, and hepatic, splenic and plasma biochemistries were assessed. Body weight increase in the 67 and 100% fat groups was significantly greater than that in the 0% fat group. Nitrogen balance was the same in all groups. Hepatic glycogen content was significantly lower in the 100% fat group than that in the 0% fat group. The weight of epididymal fat deposits was significantly lower in the 0% fat group than in the 50 and 67% fat groups. On the other hand, tissue triglyceride content and plasma lipid levels in the 100% fat group were significantly higher than in the 0% fat group, and were also higher than in the control group. It is suggested that combinations of glucose and fat have sparing effects on body fat and hepatic glycog...Continue Reading


Sep 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·K AriiY Kokuba
Oct 14, 2008·BMC Physiology·Marie-Christine BeauvieuxJean-Louis Gallis

Related Concepts

Energy Intake
Nonesterified Fatty Acids
Anhydrous Dextrose
Parenteral Nutrition

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