Comparison of glucose variability in patients with type 2 diabetes administrated glargine with needle-free jet injector and conventional insulin pen

Expert Opinion on Drug Delivery
Yixuan SunJianhua Ma

Abstract

Background: The effects of insulin delivered by needle-free jet injector on glycemic variations (GV) in patients with type 2 diabetes (T2D) which remains largely unknown.Research design and methods: We aimed to compare the glucose variability in Chinese T2D patients administrated glargine 100 U/mL (Gla-100) with a needle-free jet injector and conventional insulin pen. This was a self-comparative, observational study of 26 patients who were subjected to a flash glucose monitoring system (FGM) for 14 consecutive days. During the study period, all subjects received Gla-100 daily before breakfast using a conventional insulin pen, with the exception of day 3 and day 7, when insulin was delivered by needle-free jet injection. We analyzed FGM data of day 3, day 5, day 7, and day 9 at the endpoint.Results: There were no differences in the glycemic variability between the jet injector group and the conventional pen group. However, patients with needle-free jet injection had a lower 24 hr mean glucose (MG) and lower incremental area under the curve (AUC) of 1 hr, 12 hr, and 24 hr, compared to the conventional pen group (p = 0.001).Conclusions: Gla-100 delivered by needle-free jet injection potentially lowered MG in patients with T2D in t...Continue Reading

References

Mar 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·C M HoutzagersE A van der Veen
Jun 1, 1994·European Journal of Pediatrics·U SchneiderE Schober
Aug 2, 2001·Diabetes Technology & Therapeutics·D L Bremseth, F Pass
Mar 7, 1966·JAMA : the Journal of the American Medical Association·C Weller, M Linder
Jul 16, 2003·Clinical Therapeutics·Fei WangCunegundo M Vergara
Mar 26, 2004·Nature Reviews. Drug Discovery·Mark R PrausnitzRobert Langer
Oct 22, 2005·Nature Reviews. Immunology·Samir Mitragotri
Mar 28, 2006·Advanced Drug Delivery Reviews·Erin L Giudice, James D Campbell
Oct 27, 2006·Expert Review of Medical Devices·Joy Baxter, Samir Mitragotri
Nov 11, 2008·Nature Biotechnology·Mark R Prausnitz, Robert Langer
Feb 13, 2009·Current Medical Research and Opinion·Changyu PanHui Tian
Nov 10, 2009·Diabetes Research and Clinical Practice·J E ShawP Z Zimmet
Jan 28, 2010·Diabetes Care·Mark PeyrotLuther B Travis
Apr 28, 2012·Diabetes Technology & Therapeutics·Ronnie Aronson
Mar 19, 2014·Diabetes Research and Clinical Practice·L GuariguataJ E Shaw
Mar 19, 2016·Nature Reviews. Drug Discovery·Alexander N ZaykovRichard D DiMarchi
Jan 23, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·L Leelarathna, E G Wilmot
May 12, 2018·Clinical, Cosmetic and Investigational Dermatology·Daniel Barolet, Antranik Benohanian
Dec 12, 2018·Advanced Drug Delivery Reviews·Yuqi ZhangZhen Gu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.