Comparison of glutamate-evoked pain between the temporalis and masseter muscles in men and women

Pain
Eduardo E CastrillonPeter Svensson

Abstract

Pain in myofascial temporomandibular disorder (TMD) can affect both the masseter and temporalis muscles. Glutamate injection into the masseter muscle evokes pain that is greater in men than in women and this pain is attenuated by co-injection of the N-methyl-d-aspartate (NMDA) receptor antagonist ketamine (10 mmol/L) in men. Animal studies suggested that pain induced by peripheral NMDA receptor activation could differ between the temporalis and masseter muscles and between men and women. The study aims were to investigate differences in glutamate-evoked pain between these muscles and the effectiveness of ketamine to attenuate glutamate-evoked pain in both genders. Pain and mechanical sensitivity were induced in 2 sessions of an experiment in 14 women and 16 men by repeated injections of glutamate (0.5 mol/L) with and without ketamine (20 mmol/L) into the masseter and temporalis muscles. Two injections were applied into the same masseter muscle and 2 injections into the same anterior temporalis muscle at each session. Visual analogue scale (VAS) pain intensities and pain drawing areas were assessed. Glutamate-evoked pain and pain drawing area were significantly greater from the temporalis muscle than from the masseter muscle (P<...Continue Reading

References

Aug 1, 1989·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H C Schwartz
Nov 18, 2005·Experimental Brain Research·Brian E CairnsLars Arendt-Nielsen
May 6, 2006·Cephalalgia : an International Journal of Headache·P T Schmidt-HansenF W Bach
Mar 4, 2008·Archives of Oral Biology·Eduardo E CastrillonPeter Svensson
May 5, 2010·Journal of Oral Rehabilitation·T List, S Axelsson
Apr 5, 2011·Journal of Dental Research·S FutarmalP Svensson
Jan 6, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hisayoshi Ishii, Hiroshi Izumi

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Citations

Oct 16, 2013·Journal of the Neurological Sciences·Maria A NagelDon Gilden
Jun 29, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Youjin ChangAnne M Agur
Mar 27, 2015·European Journal of Pain : EJP·H SatoP Svensson
Aug 16, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Romain NicotJames J Sciote
Nov 2, 2016·Journal of Oral Rehabilitation·M AmhamedG M Murray
Jun 1, 2018·Somatosensory & Motor Research·Parisa Gazerani, Brian Edwin Cairns
Mar 7, 2020·Journal of Oral Science·Akimasa Tashiro, David A Bereiter
Apr 9, 2020·Frontiers in Neuroscience·Parisa Gazerani, Brian E Cairns
Apr 17, 2021·Purinergic Signalling·S J Macedo-JúniorA R S Santos

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