Comparison of glycemic and metabolic control in youth with type 1 diabetes with and without antipsychotic medication: analysis from the nationwide German/Austrian Diabetes Survey (DPV)

Diabetes Care
Angela GallerGerman Federal Ministry of Education and Research (BMBF) Competence Network Diabetes Mellitus

Abstract

The objective of this study was to explore metabolic risk factors and glycemic control in youth with type 1 diabetes treated with typical or atypical antipsychotics. Data for 60,162 subjects with type 1 diabetes up to the age of 25 years registered in the nationwide German/Austrian Diabetes Survey were included in the analysis. BMI; HbA1c; treatment strategy; prevalence of hypertension, dyslipidemia, microalbuminuria, and retinopathy; frequency of hypoglycemia and diabetic ketoacidosis (DKA); and immigrant status among subjects treated with typical or atypical antipsychotics were compared with those without antipsychotic medication and analyzed by regression analysis. A total of 291 subjects with type 1 diabetes (median diabetes duration 7.2 years) received antipsychotic medications (most commonly risperidone). Subjects treated with antipsychotics had a higher BMI (P = 0.004) and dyslipidemia was more frequent (P = 0.045) compared with subjects not receiving antipsychotic medication. Frequencies of severe hypoglycemia and DKA were significantly higher in subjects receiving antipsychotics (P < 0.001). The prevalences of hypertension, microalbuminuria, and retinopathy were not different. In subjects treated with typical antipsych...Continue Reading

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Citations

Oct 10, 2015·Diabetes Technology & Therapeutics·Nicole PrinzUNKNOWN DPV Initiative
Jul 12, 2016·Diabetologia·Fraser W GibbK Ann Lockman
Oct 19, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Thomas M KapellenKarel Kostev
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Nov 5, 2020·Journal of the American College of Emergency Physicians Open·Noritomo FujisakiAtsunori Nakao

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