PMID: 9535100Apr 16, 1998Paper

Comparison of glycine- and GABA-evoked currents in two types of neurons isolated from the rat striatum

Neuroscience Letters
O A Sergeeva

Abstract

Strychnine-sensitive glycine-activated currents and gamma-aminobutyric acid (GABA)-activated currents were compared in two types of neurons acutely isolated from striatal slices by vibrodissociation: large cells, presumably cholinergic giant aspiny neurons (GAN) and medium sized cells, presumed medium spiny neurons (MSN). Whole cell voltage clamp and concentration jump techniques were used. All cells responded to glycine (10-1000 microM) and GABA (2-100 microM), in MSN and GAN the maximal responses to glycine were 50 and 120% of the GABA response, respectively. GABA- and glycine- responses were additive and blocked selectively by bicuculline (1 microM) and strychnine (50 nM), respectively. These results predict the presence of alpha- and beta-subunits of the glycine receptor in the striatum.

References

Jul 1, 1991·Journal of Neuroscience Methods·V S Vorobjev
Jan 1, 1991·The Journal of Physiology·S Ito, E Cherubini
Aug 22, 1987·The Journal of Comparative Neurology·M Takada, T Hattori
Feb 3, 1988·Neuroscience Letters·O A KrishtalS V Vrublevsky
Aug 1, 1981·Pflügers Archiv : European journal of physiology·O P HamillF J Sigworth
Jan 1, 1982·Experimental Brain Research·U MisgeldT Ohno
Oct 1, 1996·Journal of Neuroscience Methods·V S VorobjevH L Haas

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Citations

Oct 15, 2009·Journal of Neural Transmission·Marina Sorrentino Hernandes, Lanfranco R P Troncone
Mar 24, 2000·European Journal of Pharmacology·H Sun, T K Machu
Nov 2, 2002·British Journal of Pharmacology·Olga A SergeevaHelmut L Haas
Oct 31, 2002·The European Journal of Neuroscience·A N ChepkovaO A Sergeeva
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Anna Molander, Bo Söderpalm
Aug 21, 2007·Brain Research·Marina Sorrentino HernandesLanfranco Ranieri Paolo Troncone
Jul 6, 2006·The European Journal of Neuroscience·Mia EricsonBo Söderpalm
Apr 21, 2007·The Journal of Comparative Neurology·Henry J WaldvogelRichard L M Faull
Aug 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Lindsay M McCrackenNeil L Harrison
Jan 30, 2018·Frontiers in Molecular Neuroscience·Svetlana M MolchanovaDavid Gall

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