Comparison of gonadotroph, thyrotroph and mammotroph development in situ, in transplants and in organ culture

Neuroendocrinology
D GashJ Schechter

Abstract

This study was conducted to examine the role of the hypothalamus in development of gonadotrophs, thyrotrophs, and mammotrophs up to the time of birth in the rat. The development of the in situ newborn pituitary (22 days post-coitus; dpc) was compared with the development of 12 and 15 dpc pituitary anlagen grown under the kidney capsule of an adult host or in organ culture for a time period equivalent to 22 days of gestation. Morphological development was evaluated by light microscopic histology and gonadotrophin immunocytochemistry. Functional development was analyzed by radioimmunoassay determination of luteinizing hormone, thyrotrophin, and prolactin content of the in situ, kidney capsule grafted, and organ-cultured pituitary. The results provide evidence that factors, perhaps blood-borne, play a significant role in pituitary development but that direct hypothalamic influences are of minimal importance in the development of gonadotrophs and mammotrophs. The fetal hypothalamus may play a significant role in stimulating high storage levels of thyrotrophin in the prenatal pituitary.

Citations

Sep 1, 1991·Journal of Electron Microscopy Technique·P M Dubois, F J Hemming
Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Sep 1, 1986·Molecular and Cellular Endocrinology·C J MirellJ M Hershman
Nov 1, 1989·Molecular and Cellular Endocrinology·Y A TongG Pelletier
Nov 1, 1988·Baillière's Clinical Endocrinology and Metabolism·J R DavisM C Sheppard
Jun 1, 1993·Journal of Neuroendocrinology·R TorronterasF Gracia-Navarro
Feb 1, 1986·Clinics in Endocrinology and Metabolism·C Denef

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.