Comparison of growth hormone-releasing factor and somatotropin: body growth and lactation of primiparous cows

Journal of Dairy Science
M BinelliH A Tucker

Abstract

Growth hormone-releasing factor is the main endogenous stimulator of somatotropin secretion. Our objective was to compare the effects of recombinant growth hormone-releasing factor and recombinant bST on somatotropin secretion, mammary function, and body composition of lactating, primiparous dairy cows. Cows (118 d of lactation) served as uninfused controls or were infused for 63 d with 12 mg/d of releasing factor or with 29 mg/d of bST. These doses elevated somatotropin in serum to concentrations of similar magnitude. The releasing factor and bST each similarly increased milk yield, yield of milk components, weight of most organs, mobilization of adipose tissue, accretion of lean tissue in the carcass, and metabolic activity (RNA) of mammary tissue. Relative to controls, neither releasing factor nor bST significantly affected cell numbers (DNA) in mammary glands or concentrations of plasmin in milk. None of the variables measured provided evidence for galactopoietic effects of releasing factor independent of somatotropin.

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Citations

Aug 30, 2008·DNA and Cell Biology·Patricia A BrownRuxandra Draghia-Akli
Jul 18, 2006·General and Comparative Endocrinology·Mohan MondalB S Prakash
Apr 2, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·M Mondal, B S Prakash
Jul 15, 2015·Polish Journal of Veterinary Sciences·A K DevrimM Sudagidan
Nov 7, 2006·Journal of Animal Physiology and Animal Nutrition·Mohan MondalB S Prakash
Oct 6, 1997·Journal of Dairy Science·R P RadcliffH A Tucker
Sep 13, 2006·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M SchwerinT Goldammer
Mar 6, 2004·Journal of Animal Science·A V CapucoM J Paape
Nov 15, 2001·Domestic Animal Endocrinology·R P RadcliffH A Tucker

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