Comparison of Haloperidol, Promethazine, Trifluoperazine, and Chlorpromazine in Terms of Velocity and Durability of the Sedation among Acute Aggressive Patients: A Randomized Clinical Trial

Advanced Biomedical Research
Seyed Ghafur MousaviMohammad Javad Tarrahi

Abstract

Knowledge and skill about sedation of aggressive patients is necessary for each psychiatrist. The purpose of this study was comparing the velocity and durability of sedation induced by the haloperidol, trifluoperazine, promethazine, and chlorpromazine in aggressive patients. This randomized clinical trial was done on 76 aggressive patients referred to Psychiatry Emergency Service of Noor Hospital of Isfahan University of Medical Sciences that were randomly divided into four groups of haloperidol, promethazine, chlorpromazine, and trifluoperazine. Patients were evaluated at 30 min intervals for aggressive symptoms, and if they did not respond to intervention after the first 30 min or if they showed aggression again, a same dose of the injected drug was prescribed. The length of sedation time was recorded for each patient. Seventy-six patients with the mean age of 31.89 ± 8.73 years were participated and 63.2% of them were male. Response to intervention after the first injection was seen in 40.8% and 59.2% needed the second injection. The mean time needed for obtaining sedation was 17.38 ± 8.23 and 19.66 ± 4.64 min after the first and second injection, respectively. The mean times of sedation induction were not significantly rela...Continue Reading

References

Apr 16, 2010·The Cochrane Database of Systematic Reviews·Uzair AhmedClive E Adams
Jul 9, 2014·The Cochrane Database of Systematic Reviews·Magdolna TardyStefan Leucht
Jul 10, 2014·The Cochrane Database of Systematic Reviews·Magdolna TardyStefan Leucht
Mar 10, 2015·The Cochrane Database of Systematic Reviews·Benno HartungStefan Leucht

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sedation

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