Comparison of helisal rapid blood test and 14C-urea breath test in determining Helicobacter pylori status and predicting ulcer disease in dyspeptic patients

The American Journal of Gastroenterology
C MowatK E McColl

Abstract

Noninvasive tests for Helicobacter pylori are used increasingly. Our aim was to compare the Helisal Rapid Blood (HRB) test and 14C-urea breath test (UBT) for determining H. pylori status and predicting ulcer disease. Three hundred fifty-one consecutive patients with dyspepsia (mean age 40 yr; range 16-77 yr) had an HRB test and UBT followed by endoscopy with biopsies of the antrum and body for histology and antral urease slide test (CLO test). Patients were excluded if they had previously confirmed ulcer disease, gastric surgery, or anti-H. pylori therapy or were taking nonsteroidal anti-inflammatory drugs. Sixty-three percent of the patients were "gold standard" H. pylori positive (positive CLO test, positive staining), 34% were gold standard negative (negative CLO test, negative staining), and 3% had conflicting CLO test and histology. The UBT was superior to HRB for determining H. pylori status (sensitivity 98% vs 92%, p = 0.04; specificity 100% vs 69%, p < 0.001). The specificity of the HRB decreased with increasing patient age (74% for age <46 yr; 57% for age > or =46 yr). A negative UBT was superior to a negative HRB test for predicting the absence of ulcer disease (47% vs 36 %; p < 0.01). A positive UBT was similar to a ...Continue Reading

References

Jun 1, 1989·Gut·E A RauwsG N Tytgat
Jan 11, 1997·BMJ : British Medical Journal·P MoayyediA T Axon

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Citations

Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
May 2, 2002·European Journal of Gastroenterology & Hepatology·Olga HegedusPer M Hellström
Nov 26, 1999·Alimentary Pharmacology & Therapeutics·D J KearneyJ S Peacock
Oct 26, 2000·Alimentary Pharmacology & Therapeutics·D VairaM Miglioli
Oct 17, 1998·Journal of Clinical Microbiology·W K LeungJ J Sung

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