Comparison of hemodynamic changes resulting from toxic shock syndrome toxin-1-producing Staphylococcus aureus sepsis and endotoxin-producing gram-negative rod sepsis in patients with severe burns

The Journal of Burn Care & Rehabilitation
H TanakaH Igarashi

Abstract

Five patients with burns and toxic shock syndrome toxin-1 (TSST-1)-producing Staphylococcus aureus sepsis (TSS group) were treated in a 5-year period at Kyorin University Hospital's Traumatology and Critical Care Center Burn Unit. Hemodynamic and metabolic differences in these patients were compared retrospectively with those in another five patients who were matched by burn index and age and in whom endotoxin-producing gram-negative rod sepsis developed (End group). Both groups showed hypermetabolic and hyperdynamic changes at the point sepsis developed. There were no significant differences between the two groups in any parameter. At the point septic shock developed, the TSS group showed significantly lower mean (+/- SD) arterial pressure (TSS vs End group, 64 +/- 5 vs 74 +/- 5 mm Hg; p < 0.05), significantly lower systemic vascular resistance index (TSS vs End group, 579 +/- 62 vs 729 +/- 75 dynes.sec.cm-5/m2; p < 0.05), and higher oxygen consumption (TSS vs End group, 190 +/- 7 vs 163 +/- 11 L/min/m2; p < 0.05) compared with the End group. This is the first clinical report that asserts that TSST-1-producing gram-positive sepsis may result in more hypermetabolic and hyperdynamic differences than does endotoxin-producing gram...Continue Reading

Citations

May 23, 2003·Irish Journal of Medical Science·M R KellH P Redmond
Mar 28, 2008·Future Microbiology·Elizabeth A Warner, Lyle L Moldawer
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kohei UriuKazo Kaizu
Dec 14, 2004·Journal of Ethnopharmacology·L C BragaA M A Nascimento
Oct 4, 2005·Burns : Journal of the International Society for Burn Injuries·Andrew Burd

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