PMID: 11330560May 2, 2001Paper

Comparison of hemostatic disturbances between patients on CAPD and patients on hemodialysis

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
Jolanta MalyszkoM Mysliwiec

Abstract

Disturbances in hemostasis are common findings in uremic patients. Both bleeding diathesis and thrombosis are observed. The purpose of this study was to assess whether renal replacement therapy in the form of hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD) affects coagulation and fibrinolysis in patients with end-stage renal failure. Comparison of hemostatic measures in patients on CAPD, HD, and matched healthy controls. Department of Nephrology and Internal Medicine, Bialystok University School of Medicine. Twenty-four HD patients and 23 CAPD patients were evaluated with respect to platelet aggregation, hemostatic parameters, serum lipids, lipoprotein(a), and cytokines [tumor necrosis factor alpha (TNFalpha) and interleukin-1 (IL-1)]. Four exchanges of CAPD per day, using 2.0 L dialysate over a period of 25 +/- 31 months; or 4-5 hours of HD 3 times per week for a period of 31 +/- 22 months. Platelet aggregation in whole blood and platelet-rich plasma was significantly impaired in both groups of dialyzed patients compared to healthy volunteers. Markers of endothelial cell injury (thrombomodulin and von Willebrand factor) were significantly higher in HD and CAPD patients compared to the control group. A sim...Continue Reading

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