Comparison of HER2 status between surgically resected specimens and matched biopsy specimens of gastric intestinal-type adenocarcinoma

Virchows Archiv : an International Journal of Pathology
Hiroshi YoshidaHitoshi Tsuda

Abstract

HER2 protein overexpression and gene amplification are important biomarkers for identifying gastric cancer patients who may respond to HER2-targeted therapy using trastuzumab. The aim of this study was to evaluate the concordance between HER2 protein expression and gene amplification in both surgically resected tumors and matched biopsy specimens of gastric cancer. Formalin-fixed, paraffin-embedded sections of 207 surgically resected tumors and 158 biopsy specimens from 207 cases of invasive intestinal-type gastric cancer were analyzed. Protein expression was assessed using immunohistochemistry and graded by the modified scoring criteria for gastric cancer. Gene amplification was evaluated by fluorescence in situ hybridization (FISH). HER2 overexpression was observed in 17 % of both surgically resected tumors (35/207) and biopsy specimens (26/158). HER2 gene amplification was detected in 31 % (61/200) of surgically resected tumors and 32 % (47/147) of biopsy specimens. Except for immunohistochemistry (IHC) equivocal (2+) cases, the concordance rates between IHC and FISH was 90.9 % in surgically resected tumors and 90.2 % in biopsy specimens. In IHC 2+ cases, the rate of HER2 gene amplification was 56 and 38 % in surgically rese...Continue Reading

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Citations

Jan 14, 2016·Virchows Archiv : an International Journal of Pathology·Hiroshi YoshidaNobuyoshi Hiraoka
Dec 17, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shih-Chiang HuangTse-Ching Chen
Apr 12, 2016·Indian Journal of Surgical Oncology·Raj AditiKumar Amar
Jul 2, 2016·Pathology Oncology Research : POR·Michelina AmatoAndrea Onetti Muda
May 7, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Scott A RobertsonToby C Cornish
Jan 10, 2019·American Journal of Clinical Pathology·Aaron R HuberChrista L Whitney-Miller
Dec 29, 2018·Histopathology·Philip KayeKrish Ragunath
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Jul 29, 2016·World Journal of Gastroenterology : WJG·Federica GrilloLuca Mastracci
Aug 19, 2018·Virchows Archiv : an International Journal of Pathology·Kazuki KanayamaMasatoshi Watanabe
Aug 20, 2019·World Journal of Clinical Cases·Akio KaitoTakahiro Kinoshita
Jun 26, 2020·International Cancer Conference Journal·Suguru HiroseIchinosuke Hyodo
Jan 11, 2021·Virchows Archiv : an International Journal of Pathology·Hiroshi YoshidaKan Yonemori
Aug 23, 2020·Pathology, Research and Practice·Raquel Machado-NevesAntónio Polónia
Sep 9, 2020·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Douglas RottmannNatalia Buza
May 13, 2021·Best Practice & Research. Clinical Gastroenterology·Silvia Catanese, Florian Lordick
Oct 30, 2016·Journal of Nuclear Medicine Technology·Romulo CelliDhanpat Jain

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