Comparison of high glucose concentration blood and crystalloid cardioplegia in paediatric cardiac surgery: a randomized clinical trial

Interactive Cardiovascular and Thoracic Surgery
Branko MimicMiroslav Djordjevic

Abstract

This study investigates the effects of high glucose content on patients undergoing cold crystalloid versus cold blood cardioplegia in terms of early clinical results, functional myocardial recovery and ischaemia-reperfusion injury in patients undergoing repair of acyanotic cardiac lesions. Patients were randomly assigned to receive either crystalloid (n = 31) or blood cardioplegia (n = 31). Early clinical results were assessed. Changes in left ventricular fractional shortening, arterial blood lactate levels, central venous saturation, cardiac Troponin I release and blood glucose concentration were measured during the first 24 h after ischaemia. There was no significant difference in clinical outcomes and postoperative complication rates between groups. The postoperative changes in left ventricular function, lactate levels, central venous saturation and Troponin I were not significantly different between groups. The use of crystalloid cardioplegia was associated with significant increases in serum glucose compared with blood cardioplegia. A high glucose content blood cardioplegia does not show any advantage compared with crystalloid cardioplegia in terms of clinical outcomes, functional recovery and the degree of ischaemic injur...Continue Reading

References

Dec 1, 1991·The Annals of Thoracic Surgery·H B Barner
Mar 20, 2003·The Annals of Thoracic Surgery·Hajime ImuraMassimo Caputo
May 9, 2003·The Annals of Thoracic Surgery·Torsten DoenstFriedhelm Beyersdorf
Jun 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·P ModiM Caputo
Aug 27, 2005·The Annals of Thoracic Surgery·Kerstin AmarkJan Sunnegårdh
Jul 13, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomaso BottioGiovanni Stellin
May 23, 2008·Interactive Cardiovascular and Thoracic Surgery·Mohamed F Ibrahim, Amal A Refaat
Dec 4, 2008·The Annals of Thoracic Surgery·Pranava SinhaRichard A Jonas
Dec 24, 2010·American Journal of Respiratory and Critical Care Medicine·Keith R Walley
Sep 11, 2012·The New England Journal of Medicine·Michael S D AgusUNKNOWN SPECS Study Investigators
Aug 7, 2013·The Annals of Thoracic Surgery·Yasuhiro KotaniChristopher A Caldarone

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Citations

Sep 28, 2017·Pediatric Cardiology·Konstantinos S MylonasKonstantinos P Economopoulos

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