Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression

Neuroscience Letters
Cliona M O'MahonyJohn F Cryan

Abstract

There is increasing evidence to suggest that metabotropic glutamate (mGlu) receptors including mGlu(7) receptor are important in the pathophysiology of stress-related psychiatric disorders such as anxiety and major depression. mGlu(7) receptor is highly expressed in the hippocampus, a key region involved in the modulation of depression-related behaviour. Moreover, mice deficient in mGlu(7) receptor have an antidepressant-like behaviour and altered stress response. To our knowledge there is little information as to whether stressful phenotypes can influence hippocampal mGlu(7) receptor levels. To this end, we examined hippocampal mGlu(7) receptor mRNA expression in two models of depression, the stress-sensitive Wistar Kyoto (WKY) and the maternally separated model of early-life stress. In situ hybridization analysis revealed that the WKY, but not the maternally separated (MS) rats displayed selective increases in mGlu(7) receptor mRNA expression in subregions of the hippocampus compared to relevant controls. These data suggest that higher levels of this receptor could affect the behaviour in response to stressful conditions and may play a role in WKY animal's susceptibility to stress-related disorders. However, the data in mater...Continue Reading

References

Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C López-Rubalcava, I Lucki
Jan 31, 2002·Psychoneuroendocrinology·Peter A RittenhouseIrwin Lucki
Jun 20, 2003·The European Journal of Neuroscience·John F CryanHerman van Der Putten
Jun 2, 2005·Pharmacology, Biochemistry, and Behavior·Lisa GustafssonIngrid Nylander
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kayo MitsukawaJohn F Cryan
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kayo MitsukawaPeter J Flor
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kimberly A PearsonRita J Valentino
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zsuzsanna Callaerts-VeghRudi D'Hooge
Jul 12, 2007·Psychopharmacology·Agnieszka PaluchaAndrzej Pilc
Jan 16, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S O'MahonyT G Dinan
Mar 11, 2010·Stress : the International Journal on the Biology of Stress·Dervla O'MalleyJohn F Cryan
Apr 8, 2010·European Journal of Pharmacology·Richard M O'ConnorJohn F Cryan
Jun 30, 2010·Psychopharmacology·Robert F LeemanSherry A McKee

❮ Previous
Next ❯

Citations

Apr 23, 2013·Neuropharmacology·Richard M O'ConnorJohn F Cryan
Sep 9, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua LiRichard C Shelton
May 4, 2011·Pharmacology, Biochemistry, and Behavior·Kenichi TokitaKenji Hashimoto
Jan 30, 2016·Current Behavioral Neuroscience Reports·Minkyung ParkCarlos A Zarate
Jul 31, 2021·World Journal of Psychiatry·Adejoke Yetunde Onaolapo, Olakunle James Onaolapo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.