Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time.

PloS One
Dineke FrentzDavid A M C van de Vijver

Abstract

Several decision support systems have been developed to interpret HIV-1 drug resistance genotyping results. This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford's HIVdb) to predict virological outcome at 12, 24, and 48 weeks. Included were 3763 treatment-change episodes (TCEs) for which a HIV-1 genotype was available at the time of changing treatment with at least one follow-up viral load measurement. Genotypic susceptibility scores for the active regimens were calculated using scores defined by each interpretation system. Using logistic regression, we determined the association between the genotypic susceptibility score and proportion of TCEs having an undetectable viral load (<50 copies/ml) at 12 (8-16) weeks (2152 TCEs), 24 (16-32) weeks (2570 TCEs), and 48 (44-52) weeks (1083 TCEs). The Area under the ROC curve was calculated using a 10-fold cross-validation to compare the different interpretation systems regarding the sensitivity and specificity for predicting undetectable viral load. The mean genotypic susceptibility score of the systems was slightly smaller for HIVdb, with 1.92+/-1.17, compared to Rega and ANRS, with 2.22+/-1.09 and 2.23+/-1.05, respectively. However, similar odds r...Continue Reading

References

Jan 25, 2002·AIDS·Cristina TuralUNKNOWN Havana Study Group
Jan 31, 2002·Journal of Biomedical Optics·Andrew M RollinsJoseph A Izatt
Jun 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jaideep RavelaRobert W Shafer
May 20, 2004·Drug Discovery Today·Carlos F Amábile-Cuevas, Jack A Heinemann
May 3, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tommy F Liu, Robert W Shafer
Jun 14, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin S HirschDouglas D Richman
Nov 27, 2008·AIDS Research and Human Retroviruses·Salima BouzeghoubHervé J Fleury
Jun 3, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·P M A SlootM Bubak
Jun 26, 2009·The Journal of Infectious Diseases·Soo-Yon RheeRobert W Shafer

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Citations

Jan 17, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A Gonzalez-SernaL C Swenson
May 31, 2012·Antimicrobial Agents and Chemotherapy·Milan KozísekJochen Bodem
Sep 7, 2013·PLoS Computational Biology·Niko BeerenwinkelUNKNOWN Swiss HIV Cohort Study
Jun 8, 2011·Current Opinion in HIV and AIDS·David T DunnPatricia A Cane
Oct 31, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·T Lengauer
Jun 27, 2015·Current Opinion in Virology·Kristel Van LaethemAnne-Mieke Vandamme
Jan 2, 2015·AIDS Research and Therapy·Gloria Huerta-GarcíaJesús Gaytán-Martínez
Sep 29, 2015·AIDS Research and Therapy·José Antonio Mata-MarínJesús Gaytán-Martínez
Jul 12, 2013·ISRN Microbiology·Maria Mercedes Santoro, Carlo Federico Perno
May 6, 2017·Briefings in Bioinformatics·Zhen ShengZhiwei Cao
Dec 20, 2017·Open Forum Infectious Diseases·Seema T MeloniPhyllis J Kanki
Aug 22, 2014·Journal of the International AIDS Society·Awachana JiamsakulUNKNOWN TREAT Asia Studies to Evaluate Resistance – Monitoring Study (TASER-M)
Jun 8, 2012·Nature Reviews. Cancer·Christoph Bock, Thomas Lengauer
Dec 22, 2017·Current Opinion in HIV and AIDS·David A M C van de Vijver, Charles A B Boucher
May 21, 2014·Molecular Biology Reports·Nazli JafarpourMehdi Mahdavi
Dec 18, 2019·BMC Public Health·Nadine KronfliMarina B Klein
Oct 17, 2017·AIDS Research and Therapy·Seema T MeloniPhyllis J Kanki
Jun 30, 2016·Southern African Journal of HIV Medicine·Andrew RevellBrendan Larder
Jul 28, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Huldrych F GünthardDouglas D Richman

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Methods Mentioned

BETA
genotyping

Software Mentioned

Rega
SPSS
Stanford
ANRS
ViroLab
HIVdb
EuResist

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