Comparison of HIV oral fluid and plasma antibody results during early infection in a longitudinal Nigerian cohort

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Wei LuoS M Owen

Abstract

Oral fluid (OF) testing is a less-invasive alternative to blood-based testing for HIV. The performance of HIV OF tests has not been extensively evaluated in serially collected paired specimens from seroconverters. To compare paired OF and plasma test performance in a cohort of HIV-1 seroconverters from Nigeria. Paired plasma and OF specimens from 14 seroconverters collected during 24 months of longitudinal follow up were included in the study. Plasma and OF were tested using Avioq HIV-1 Microelisa System, and first reactivity in plasma and OF specimens was compared. OF specimens reactive by Avioq were subsequently tested by OraSure HIV-1 Western blot. Genetic Systems HIV-1 Western blot was also performed on the corresponding plasma of the first 2 Avioq-OF positive time-points. Of the 14 seroconverters, 5 (35.7%) had concordant results between plasma and OF for all time points tested, whereas 9 (64.3%) showed reactivity on plasma before OF specimens early in infection. The median delay between plasma and OF reactivity was 29 days (range: 0 day-20 months) (p<0.0039); the median overall delay for OF compared to RNA testing was 69.5 days. Delayed antibody response with OF was observed in both males and females regardless of viral l...Continue Reading

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Citations

Sep 26, 2015·PLoS Neglected Tropical Diseases·Anne-Claire AndriesPhilippe Buchy
Nov 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kevin P DelaneySherry Michele Owen
Apr 4, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marcel E CurlinUNKNOWN OraQuick Study Group
Nov 16, 2017·Sexually Transmitted Diseases·Christopher B HurtWilliam C Miller
May 26, 2017·Journal of Clinical Microbiology·Thomas R Kozel, Amanda R Burnham-Marusich
Jan 24, 2018·Proceedings of the National Academy of Sciences of the United States of America·Cheng-Ting TsaiCarolyn R Bertozzi
Aug 29, 2016·International Urology and Nephrology·Laura E LambMichael B Chancellor
Jan 20, 2021·ACS Biomaterials Science & Engineering·Tobias MieslerLorenz Meinel

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