Comparison of human and Xenopus GATA-2 promoters

Gene
D E FleenorR E Kaufman

Abstract

GATA proteins comprise a family of transcription factors that are required for appropriate development of hematopoietic lineages. In order to understand the transcriptional regulation of GATA genes, we have cloned the human GATA-2 gene and identified and characterized its promoter. Comparison with the Xenopus GATA-2 promoter demonstrates highly conserved CCAAT box elements, which are essential for appropriate Xenopus expression. Unlike the Xenopus gene, the human GATA-2 gene lacks GATA binding motifs within the first 800 bp of 5' flanking sequence. In addition, the human GATA-2 promoter has two highly conserved ets sites that resemble the binding site for a recently described ets repressor factor, ERF. These conserved DNA sequence motifs provide strong candidate regions for the regulation of GATA-2.

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Citations

Jan 17, 2013·The Journal of Biological Chemistry·Erin Eun-Young AhnDong-Er Zhang
Aug 3, 2005·Nucleic Acids Research·Tal OrenTodd Evans
Sep 26, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bohao ChenJulian Solway
Sep 10, 2002·Developmental Biology·Asanka KarunaratneToshiya Yamada
Mar 7, 1998·The Journal of Biological Chemistry·N MinegishiM Yamamoto

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